Ionic charge transport between blockages: Sodium cation conduction in freshly excised bulk brain tissue

Journal Article · Sat Aug 15 00:00:00 EDT 2015 · AIP Advances

DOI:https://doi.org/10.1063/1.4928652· OSTI ID:22492309

Emin, David ^[1]; Akhtari, Massoud ^[2]; Ellingson, B. M. ^[3]; Mathern, G. W. ^[4]

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1. Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131 (United States)
2. Semple Institutes for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 (United States)
3. Department of Radiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 (United States)
4. Department of Neurosurgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 (United States)

We analyze the transient-dc and frequency-dependent electrical conductivities between blocking electrodes. We extend this analysis to measurements of ions’ transport in freshly excised bulk samples of human brain tissue whose complex cellular structure produces blockages. The associated ionic charge-carrier density and diffusivity are consistent with local values for sodium cations determined non-invasively in brain tissue by MRI (NMR) and diffusion-MRI (spin-echo NMR). The characteristic separation between blockages, about 450 microns, is very much shorter than that found for sodium-doped gel proxies for brain tissue, >1 cm.

• OSTI ID: 22492309
• Journal Information: AIP Advances, Vol. 5, Issue 8; Other Information: (c) 2015 Author(s); Country of input: International Atomic Energy Agency (IAEA); ISSN 2158-3226
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
ANIMAL TISSUES
BRAIN
CATIONS
CHANNELING
CHARGE CARRIERS
CHARGE TRANSPORT
DIFFUSION
DOPED MATERIALS
ELECTRIC CONDUCTIVITY
FREQUENCY DEPENDENCE
GELS
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
SODIUM
SPIN ECHO
TRANSIENTS