Fabrication of submicron proteinaceous structures by direct laser writing

Journal Article · Mon Jul 06 00:00:00 EDT 2015 · Applied Physics Letters

DOI:https://doi.org/10.1063/1.4926659· OSTI ID:22483164

Serien, Daniela ^[1]; Takeuchi, Shoji ^[1]

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1. Center for International Research on Integrative Biomedical Systems, Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, 153-8505 Tokyo (Japan)

In this paper, we provide a characterization of truly free-standing proteinaceous structures with submicron feature sizes depending on the fabrication conditions by model-based analysis. Protein cross-linking of bovine serum albumin is performed by direct laser writing and two-photon excitation of flavin adenine dinucleotide. We analyze the obtainable fabrication resolution and required threshold energy for polymerization. The applied polymerization model allows prediction of fabrication conditions and resulting fabrication size, alleviating the application of proteinaceous structure fabrication.

• OSTI ID: 22483164
• Journal Information: Applied Physics Letters, Vol. 107, Issue 1; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0003-6951
• Country of Publication: United States
• Language: English

Related Subjects

71 CLASSICAL AND QUANTUM MECHANICS
GENERAL PHYSICS
ADENINES
ALBUMINS
CATTLE
CROSS-LINKING
EXCITATION
FABRICATION
LASERS
PHOTONS
RESOLUTION
THRESHOLD ENERGY