Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation

Journal Article · Fri Apr 17 00:00:00 EDT 2015 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2015.03.001· OSTI ID:22462005

Li, Zheng Jun; Shin, Jung-Min; Choi, Dae-Kyoung; Lim, Seul Ki ^[1]; Yoon, Tae-Jin ^[2]; Lee, Young Ho ^[3]; Sohn, Kyung-Cheol; Im, Myung; Lee, Young; Seo, Young-Joon; Kim, Chang Deok ^[1]; Lee, Jeung-Hoon ^[1]

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1. Department of Dermatology, School of Medicine, Chungnam National University, Daejeon (Korea, Republic of)
2. Department of Dermatology, School of Medicine, Gyeongsang National University, Jinju (Korea, Republic of)
3. Department of Anatomy, School of Medicine, Chungnam National University, Daejeon (Korea, Republic of)

Psoriasis is a common skin disease, of which pathogenesis involves the increase of inflammatory reaction in epidermal cells. In an attempt to find therapeutics for psoriasis, we found that cucurbitacin B has an inhibitory potential on imiquimod-induced inflammation of keratinocytes. Cucurbitacin B significantly inhibited imiquimod-induced expression of crucial psoriatic cytokines, such as IL-8 and CCL20, via down-regulation of NF-κB and STAT3 signaling pathway in human keratinocytes. In addition, keratinocyte proliferation was markedly inhibited by cucurbitacin B. The potential beneficial effect of cucurbitacin B on psoriasis was further validated in imiquimod-induced psoriasiform dermatitis of experimental animal. Topical application of cucurbitacin B resulted in significant reduction of epidermal hyperplasia and inflammatory cytokines production, and ameliorated the psoriatic symptom. Taken together, these results suggest that cucurbitacin B may be a potential candidate for the treatment of psoriasis. - Highlights: • Cucurbitacin B has a potential for inhibiting the growth of keratinocytes. • Cucurbitacin B inhibits imiquimod-induced inflammatory reaction in keratinocytes. • Cucurbitacin B inhibits imiquimod-induced psoriasiform dermatitis in experimental animal.

• OSTI ID: 22462005
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 459, Issue 4; Other Information: Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
DERMATITIS
HUMAN POPULATIONS
INFLAMMATION
LYMPHOKINES
PATHOGENESIS
PLANT GROWTH
PSORIASIS
SIGNALS
SKIN