Protection of non-human primates against rabies with an adenovirus recombinant vaccine
Abstract
Rabies remains a major neglected global zoonosis. New vaccine strategies are needed for human rabies prophylaxis. A single intramuscular immunization with a moderate dose of an experimental chimpanzee adenovirus (Ad) vector serotype SAd-V24, also termed AdC68, expressing the rabies virus glycoprotein, resulted in sustained titers of rabies virus neutralizing antibodies and protection against a lethal rabies virus challenge infection in a non-human primate model. Taken together, these data demonstrate the safety, immunogenicity, and efficacy of the recombinant Ad-rabies vector for further consideration in human clinical trials. - Highlights: • Pre-exposure vaccination with vaccine based on a chimpanzee derived adenovirus protects against rabies. • Protection is sustained. • Protection is achieved with single low-dose of vaccine given intramuscularly. • Protection is not affected by pre-existing antibodies to common human serotypes of adenovirus.
- Authors:
-
- The Wistar Institute of Anatomy and Biology, Philadelphia, PA (United States)
- Centers for Disease Control and Prevention, Atlanta, GA (United States)
- The Global Alliance for Rabies Control, Manhattan, KS (United States)
- Publication Date:
- OSTI Identifier:
- 22435016
- Resource Type:
- Journal Article
- Journal Name:
- Virology
- Additional Journal Information:
- Journal Volume: 450-451; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0042-6822
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; ADENOVIRUS; ANTIBODIES; CLINICAL TRIALS; DOSES; GLYCOPROTEINS; HUMAN POPULATIONS; PREVENTIVE MEDICINE; PRIMATES; RABIES; SAFETY; VACCINES
Citation Formats
Xiang, Z. Q., Greenberg, L., Ertl, H.C., E-mail: ertl@wistar.upenn.edu, Rupprecht, C. E., and Ross University School of Veterinary Medicine, Basseterre. Protection of non-human primates against rabies with an adenovirus recombinant vaccine. United States: N. p., 2014.
Web. doi:10.1016/J.VIROL.2013.12.029.
Xiang, Z. Q., Greenberg, L., Ertl, H.C., E-mail: ertl@wistar.upenn.edu, Rupprecht, C. E., & Ross University School of Veterinary Medicine, Basseterre. Protection of non-human primates against rabies with an adenovirus recombinant vaccine. United States. https://doi.org/10.1016/J.VIROL.2013.12.029
Xiang, Z. Q., Greenberg, L., Ertl, H.C., E-mail: ertl@wistar.upenn.edu, Rupprecht, C. E., and Ross University School of Veterinary Medicine, Basseterre. 2014.
"Protection of non-human primates against rabies with an adenovirus recombinant vaccine". United States. https://doi.org/10.1016/J.VIROL.2013.12.029.
@article{osti_22435016,
title = {Protection of non-human primates against rabies with an adenovirus recombinant vaccine},
author = {Xiang, Z. Q. and Greenberg, L. and Ertl, H.C., E-mail: ertl@wistar.upenn.edu and Rupprecht, C. E. and Ross University School of Veterinary Medicine, Basseterre},
abstractNote = {Rabies remains a major neglected global zoonosis. New vaccine strategies are needed for human rabies prophylaxis. A single intramuscular immunization with a moderate dose of an experimental chimpanzee adenovirus (Ad) vector serotype SAd-V24, also termed AdC68, expressing the rabies virus glycoprotein, resulted in sustained titers of rabies virus neutralizing antibodies and protection against a lethal rabies virus challenge infection in a non-human primate model. Taken together, these data demonstrate the safety, immunogenicity, and efficacy of the recombinant Ad-rabies vector for further consideration in human clinical trials. - Highlights: • Pre-exposure vaccination with vaccine based on a chimpanzee derived adenovirus protects against rabies. • Protection is sustained. • Protection is achieved with single low-dose of vaccine given intramuscularly. • Protection is not affected by pre-existing antibodies to common human serotypes of adenovirus.},
doi = {10.1016/J.VIROL.2013.12.029},
url = {https://www.osti.gov/biblio/22435016},
journal = {Virology},
issn = {0042-6822},
number = ,
volume = 450-451,
place = {United States},
year = {Sat Feb 15 00:00:00 EST 2014},
month = {Sat Feb 15 00:00:00 EST 2014}
}