{sup 18}F-Choline Positron Emission Tomography/Computed Tomography–Driven High-Dose Salvage Radiation Therapy in Patients With Biochemical Progression After Radical Prostatectomy: Feasibility Study in 60 Patients

Sciuto, Rosa; Ramella, Sara; Papalia, Rocco; Jereczek-Fossa, Barbara A.; Trodella, Luca E.; Fiore, Michele; Gallucci, Michele; Maini, Carlo L.; Trodella, Lucio

doi:10.1016/J.IJROBP.2014.05.050

Title: {sup 18}F-Choline Positron Emission Tomography/Computed Tomography–Driven High-Dose Salvage Radiation Therapy in Patients With Biochemical Progression After Radical Prostatectomy: Feasibility Study in 60 Patients

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Abstract

Purpose: To retrospectively review data of a cohort of patients with biochemical progression after radical prostatectomy, treated according to a uniform institutional treatment policy, to evaluate toxicity and feasibility of high-dose salvage radiation therapy (80 Gy). Methods and Materials: Data on 60 patients with biochemical progression after radical prostatectomy between January 2009 and September 2011 were reviewed. The median value of prostate-specific antigen before radiation therapy was 0.9 ng/mL. All patients at time of diagnosis of biochemical recurrence underwent dynamic {sup 18}F-choline positron emission tomography/computed tomography (PET/CT), which revealed in all cases a local recurrence. High-dose salvage radiation therapy was delivered up to total dose of 80 Gy to 18F-choline PET/CT-positive area. Toxicity was recorded according to the Common Terminology Criteria for Adverse Events, version 3.0, scale. Results: Treatment was generally well tolerated: 54 patients (90%) completed salvage radiation therapy without any interruption. Gastrointestinal grade ≥2 acute toxicity was recorded in 6 patients (10%), whereas no patient experienced a grade ≥2 genitourinary toxicity. No grade 4 acute toxicity events were recorded. Only 1 patient (1.7%) experienced a grade 2 gastrointestinal late toxicity. With a mean follow-up of 31.2 months, 46 of 60 patients (76.6%) were free of recurrence. The 3-year biochemical progression-free survival rate wasmore »« less

Authors:

Sciuto, Rosa ^[1]; Ramella, Sara ^[2]; Papalia, Rocco ^[3]; Jereczek-Fossa, Barbara A. ^[4]; Trodella, Luca E.; Fiore, Michele ^[2]; Gallucci, Michele ^[3]; Maini, Carlo L. ^[1]; Trodella, Lucio ^[2]

Department of Nuclear Medicine, Regina Elena National Cancer Institute, Rome (Italy)
Radiation Oncology, Campus Bio-Medico University, Rome (Italy)
Department of Urology, Regina Elena National Cancer Institute, Rome (Italy)
Department of Radiation Oncology, European Institute of Oncology, Milan (Italy)

Publication Date:: Wed Oct 01 00:00:00 EDT 2014

OSTI Identifier:: 22423813

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 90; Journal Issue: 2; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; ANTIGENS; CHOLINE; DIAGNOSIS; FEASIBILITY STUDIES; FLUORINE 18; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; PROSTATE; RADIATION DOSES; RADIOTHERAPY; REVIEWS; TOXICITY

Citation Formats


                    D'Angelillo, Rolando M., E-mail: r.dangelillo@unicampus.it, Sciuto, Rosa, Ramella, Sara, Papalia, Rocco, Jereczek-Fossa, Barbara A., Department of Health Sciences, University of Milan, Milan, Trodella, Luca E., Fiore, Michele, Gallucci, Michele, Maini, Carlo L., and Trodella, Lucio. {sup 18}F-Choline Positron Emission Tomography/Computed Tomography–Driven High-Dose Salvage Radiation Therapy in Patients With Biochemical Progression After Radical Prostatectomy: Feasibility Study in 60 Patients.  United States: N. p., 2014. 
        Web.  doi:10.1016/J.IJROBP.2014.05.050.

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                    D'Angelillo, Rolando M., E-mail: r.dangelillo@unicampus.it, Sciuto, Rosa, Ramella, Sara, Papalia, Rocco, Jereczek-Fossa, Barbara A., Department of Health Sciences, University of Milan, Milan, Trodella, Luca E., Fiore, Michele, Gallucci, Michele, Maini, Carlo L., & Trodella, Lucio. {sup 18}F-Choline Positron Emission Tomography/Computed Tomography–Driven High-Dose Salvage Radiation Therapy in Patients With Biochemical Progression After Radical Prostatectomy: Feasibility Study in 60 Patients.  United States.  https://doi.org/10.1016/J.IJROBP.2014.05.050

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                    D'Angelillo, Rolando M., E-mail: r.dangelillo@unicampus.it, Sciuto, Rosa, Ramella, Sara, Papalia, Rocco, Jereczek-Fossa, Barbara A., Department of Health Sciences, University of Milan, Milan, Trodella, Luca E., Fiore, Michele, Gallucci, Michele, Maini, Carlo L., and Trodella, Lucio. 2014.  
        "{sup 18}F-Choline Positron Emission Tomography/Computed Tomography–Driven High-Dose Salvage Radiation Therapy in Patients With Biochemical Progression After Radical Prostatectomy: Feasibility Study in 60 Patients".  United States.  https://doi.org/10.1016/J.IJROBP.2014.05.050.

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@article{osti_22423813,

  title        = {{sup 18}F-Choline Positron Emission Tomography/Computed Tomography–Driven High-Dose Salvage Radiation Therapy in Patients With Biochemical Progression After Radical Prostatectomy: Feasibility Study in 60 Patients},

  author       = {D'Angelillo, Rolando M., E-mail: r.dangelillo@unicampus.it and Sciuto, Rosa and Ramella, Sara and Papalia, Rocco and Jereczek-Fossa, Barbara A. and Department of Health Sciences, University of Milan, Milan and Trodella, Luca E. and Fiore, Michele and Gallucci, Michele and Maini, Carlo L. and Trodella, Lucio},

  abstractNote = {Purpose: To retrospectively review data of a cohort of patients with biochemical progression after radical prostatectomy, treated according to a uniform institutional treatment policy, to evaluate toxicity and feasibility of high-dose salvage radiation therapy (80 Gy). Methods and Materials: Data on 60 patients with biochemical progression after radical prostatectomy between January 2009 and September 2011 were reviewed. The median value of prostate-specific antigen before radiation therapy was 0.9 ng/mL. All patients at time of diagnosis of biochemical recurrence underwent dynamic {sup 18}F-choline positron emission tomography/computed tomography (PET/CT), which revealed in all cases a local recurrence. High-dose salvage radiation therapy was delivered up to total dose of 80 Gy to 18F-choline PET/CT-positive area. Toxicity was recorded according to the Common Terminology Criteria for Adverse Events, version 3.0, scale. Results: Treatment was generally well tolerated: 54 patients (90%) completed salvage radiation therapy without any interruption. Gastrointestinal grade ≥2 acute toxicity was recorded in 6 patients (10%), whereas no patient experienced a grade ≥2 genitourinary toxicity. No grade 4 acute toxicity events were recorded. Only 1 patient (1.7%) experienced a grade 2 gastrointestinal late toxicity. With a mean follow-up of 31.2 months, 46 of 60 patients (76.6%) were free of recurrence. The 3-year biochemical progression-free survival rate was 72.5%. Conclusions: At early follow-up, {sup 18}F-choline PET/CT-driven high-dose salvage radiation therapy seems to be feasible and well tolerated, with a low rate of toxicity.},

  doi          = {10.1016/J.IJROBP.2014.05.050},

  url          = {https://www.osti.gov/biblio/22423813},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 2,

  volume       = 90,

  place        = {United States},

  year         = {Wed Oct 01 00:00:00 EDT 2014},

  month        = {Wed Oct 01 00:00:00 EDT 2014}

}

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