Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite for targeted drug delivery
Abstract
Highlights: • Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite was synthesized by a simple, efficient and environmental friendly method. • The prepared material had a large surface area, high pore volume, and good magnetic separability. • DOX-loaded Fe{sub 3}O{sub 4}/hydroxyapatite composite exhibited surprising slow drug release behavior and pH-dependent behavior. - Abstract: In this contribution, we introduced a simple, efficient, and green method of preparing a mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite (HA) composite. The as-prepared material had a large surface area, high pore volume, and good magnetic separability, which made it suitable for targeted drug delivery systems. The chemotherapeutic agent doxorubicin (DOX) was used to investigate the drug release behavior of Fe{sub 3}O{sub 4}/HA composite. The drug release profiles displayed a little burst effect and pH-dependent behavior. The release rate of DOX at pH 5.8 was larger than that at pH 7.4, which could be attributed to DOX protonation in acid medium. In addition, the released DOX concentrations remained at 0.83 and 1.39 μg/ml at pH 7.4 and 5.8, respectively, which indicated slow, steady, and safe release rates. Therefore, the as-prepared Fe{sub 3}O{sub 4}/hydroxyapatite composite could be an efficient platform for targeted anticancer drug delivery.
- Authors:
- Publication Date:
- OSTI Identifier:
- 22420605
- Resource Type:
- Journal Article
- Journal Name:
- Materials Research Bulletin
- Additional Journal Information:
- Journal Volume: 59; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0025-5408
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; APATITES; COMPOSITE MATERIALS; CONCENTRATION RATIO; DOXORUBICIN; FERRITES; IRON OXIDES; NANOSTRUCTURES; PH VALUE; SURFACE AREA; SYNTHESIS
Citation Formats
Gu, Lina, He, Xiaomei, and Wu, Zhenyu. Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite for targeted drug delivery. United States: N. p., 2014.
Web. doi:10.1016/J.MATERRESBULL.2014.06.018.
Gu, Lina, He, Xiaomei, & Wu, Zhenyu. Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite for targeted drug delivery. United States. https://doi.org/10.1016/J.MATERRESBULL.2014.06.018
Gu, Lina, He, Xiaomei, and Wu, Zhenyu. 2014.
"Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite for targeted drug delivery". United States. https://doi.org/10.1016/J.MATERRESBULL.2014.06.018.
@article{osti_22420605,
title = {Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite for targeted drug delivery},
author = {Gu, Lina and He, Xiaomei and Wu, Zhenyu},
abstractNote = {Highlights: • Mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite composite was synthesized by a simple, efficient and environmental friendly method. • The prepared material had a large surface area, high pore volume, and good magnetic separability. • DOX-loaded Fe{sub 3}O{sub 4}/hydroxyapatite composite exhibited surprising slow drug release behavior and pH-dependent behavior. - Abstract: In this contribution, we introduced a simple, efficient, and green method of preparing a mesoporous Fe{sub 3}O{sub 4}/hydroxyapatite (HA) composite. The as-prepared material had a large surface area, high pore volume, and good magnetic separability, which made it suitable for targeted drug delivery systems. The chemotherapeutic agent doxorubicin (DOX) was used to investigate the drug release behavior of Fe{sub 3}O{sub 4}/HA composite. The drug release profiles displayed a little burst effect and pH-dependent behavior. The release rate of DOX at pH 5.8 was larger than that at pH 7.4, which could be attributed to DOX protonation in acid medium. In addition, the released DOX concentrations remained at 0.83 and 1.39 μg/ml at pH 7.4 and 5.8, respectively, which indicated slow, steady, and safe release rates. Therefore, the as-prepared Fe{sub 3}O{sub 4}/hydroxyapatite composite could be an efficient platform for targeted anticancer drug delivery.},
doi = {10.1016/J.MATERRESBULL.2014.06.018},
url = {https://www.osti.gov/biblio/22420605},
journal = {Materials Research Bulletin},
issn = {0025-5408},
number = ,
volume = 59,
place = {United States},
year = {Sat Nov 15 00:00:00 EST 2014},
month = {Sat Nov 15 00:00:00 EST 2014}
}