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Title: Predicting Outcome in Patients with Rhabdomyosarcoma: Role of [{sup 18}F]Fluorodeoxyglucose Positron Emission Tomography

Abstract

Purpose: To evaluate whether [{sup 18}F]fluorodeoxyglucose positron emission tomography (FDG-PET) response of the primary tumor after induction chemotherapy predicts outcomes in rhabdomyosarcoma (RMS). Methods and Materials: After excluding those with initial tumor resection, 107 patients who underwent FDG-PET after induction chemotherapy at Memorial Sloan Kettering Cancer Center from 2002 to 2013 were reviewed. Local control (LC), progression-free survival (PFS), and overall survival (OS) were calculated according to FDG-PET response and maximum standardized uptake value (SUV) at baseline (PET1/SUV1), after induction chemotherapy (PET2/SUV2), and after local therapy (PET3/SUV3). Receiver operator characteristic curves were used to determine the optimal cutoff for dichotomization of SUV1 and SUV2 values. Results: The SUV1 (<9.5 vs ≥9.5) was predictive of PFS (P=.02) and OS (P=.02), but not LC. After 12 weeks (median) of induction chemotherapy, 45 patients had negative PET2 scans and 62 had positive scans: 3-year PFS was 72% versus 44%, respectively (P=.01). The SUV2 (<1.5 vs ≥1.5) was similarly predictive of PFS (P=.005) and was associated with LC (P=.02) and OS (P=.03). A positive PET3 scan was predictive of worse PFS (P=.0009), LC (P=.05), and OS (P=.03). Conclusions: [{sup 18}F]fluorodeoxyglucose positron emission tomography is an early indicator of outcomes in patients with RMS. Future prospective trials may incorporatemore » FDG-PET response data for risk-adapted therapy and early assessment of new treatment regimens.« less

Authors:
 [1];  [2];  [3];  [1];  [3];  [2]
  1. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York (United States)
  2. Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York (United States)
  3. Department of Nuclear Medicine, Memorial Sloan Kettering Cancer Center, New York, New York (United States)
Publication Date:
OSTI Identifier:
22420506
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 90; Journal Issue: 5; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; FLUORINE 18; FLUORODEOXYGLUCOSE; HAZARDS; NEOPLASMS; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; UPTAKE

Citation Formats

Casey, Dana L., Wexler, Leonard H., Fox, Josef J., Dharmarajan, Kavita V., Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, Schoder, Heiko, Price, Alison N., Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania, and Wolden, Suzanne L., E-mail: woldens@mskcc.org. Predicting Outcome in Patients with Rhabdomyosarcoma: Role of [{sup 18}F]Fluorodeoxyglucose Positron Emission Tomography. United States: N. p., 2014. Web. doi:10.1016/J.IJROBP.2014.08.005.
Casey, Dana L., Wexler, Leonard H., Fox, Josef J., Dharmarajan, Kavita V., Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, Schoder, Heiko, Price, Alison N., Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania, & Wolden, Suzanne L., E-mail: woldens@mskcc.org. Predicting Outcome in Patients with Rhabdomyosarcoma: Role of [{sup 18}F]Fluorodeoxyglucose Positron Emission Tomography. United States. https://doi.org/10.1016/J.IJROBP.2014.08.005
Casey, Dana L., Wexler, Leonard H., Fox, Josef J., Dharmarajan, Kavita V., Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, Schoder, Heiko, Price, Alison N., Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania, and Wolden, Suzanne L., E-mail: woldens@mskcc.org. 2014. "Predicting Outcome in Patients with Rhabdomyosarcoma: Role of [{sup 18}F]Fluorodeoxyglucose Positron Emission Tomography". United States. https://doi.org/10.1016/J.IJROBP.2014.08.005.
@article{osti_22420506,
title = {Predicting Outcome in Patients with Rhabdomyosarcoma: Role of [{sup 18}F]Fluorodeoxyglucose Positron Emission Tomography},
author = {Casey, Dana L. and Wexler, Leonard H. and Fox, Josef J. and Dharmarajan, Kavita V. and Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York and Schoder, Heiko and Price, Alison N. and Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania and Wolden, Suzanne L., E-mail: woldens@mskcc.org},
abstractNote = {Purpose: To evaluate whether [{sup 18}F]fluorodeoxyglucose positron emission tomography (FDG-PET) response of the primary tumor after induction chemotherapy predicts outcomes in rhabdomyosarcoma (RMS). Methods and Materials: After excluding those with initial tumor resection, 107 patients who underwent FDG-PET after induction chemotherapy at Memorial Sloan Kettering Cancer Center from 2002 to 2013 were reviewed. Local control (LC), progression-free survival (PFS), and overall survival (OS) were calculated according to FDG-PET response and maximum standardized uptake value (SUV) at baseline (PET1/SUV1), after induction chemotherapy (PET2/SUV2), and after local therapy (PET3/SUV3). Receiver operator characteristic curves were used to determine the optimal cutoff for dichotomization of SUV1 and SUV2 values. Results: The SUV1 (<9.5 vs ≥9.5) was predictive of PFS (P=.02) and OS (P=.02), but not LC. After 12 weeks (median) of induction chemotherapy, 45 patients had negative PET2 scans and 62 had positive scans: 3-year PFS was 72% versus 44%, respectively (P=.01). The SUV2 (<1.5 vs ≥1.5) was similarly predictive of PFS (P=.005) and was associated with LC (P=.02) and OS (P=.03). A positive PET3 scan was predictive of worse PFS (P=.0009), LC (P=.05), and OS (P=.03). Conclusions: [{sup 18}F]fluorodeoxyglucose positron emission tomography is an early indicator of outcomes in patients with RMS. Future prospective trials may incorporate FDG-PET response data for risk-adapted therapy and early assessment of new treatment regimens.},
doi = {10.1016/J.IJROBP.2014.08.005},
url = {https://www.osti.gov/biblio/22420506}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 90,
place = {United States},
year = {Mon Dec 01 00:00:00 EST 2014},
month = {Mon Dec 01 00:00:00 EST 2014}
}