Proton Radiation Therapy for the Treatment of Retinoblastoma
Abstract
Purpose: To investigate long-term disease and toxicity outcomes for pediatric retinoblastoma patients treated with proton radiation therapy (PRT). Methods and Materials: This is a retrospective analysis of 49 retinoblastoma patients (60 eyes) treated with PRT between 1986 and 2012. Results: The majority (84%) of patients had bilateral disease, and nearly half (45%) had received prior chemotherapy. At a median follow-up of 8 years (range, 1-24 years), no patients died of retinoblastoma or developed metastatic disease. The post-PRT enucleation rate was low (18%), especially in patients with early-stage disease (11% for patients with International Classification for Intraocular Retinoblastoma [ICIR] stage A-B disease vs 23% for patients with ICIR stage C-D disease). Post-PRT ophthalmologic follow-up was available for 61% of the preserved eyes (30 of 49): 14 of 30 eyes (47%) had 20/40 visual acuity or better, 7 of 30 (23%) had moderate visual acuity (20/40-20/600), and 9 of 30 (30%) had little or no useful vision (worse than 20/600). Twelve of 60 treated eyes (20%) experienced a post-PRT event requiring intervention, with cataracts the most common (4 eyes). No patients developed an in-field second malignancy. Conclusions: Long-term follow-up of retinoblastoma patients treated with PRT demonstrates that PRT can achieve high local control rates, evenmore »
- Authors:
-
- Harvard Radiation Oncology Program, Boston, Massachusetts (United States)
- Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)
- Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts (United States)
- Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts (United States)
- Publication Date:
- OSTI Identifier:
- 22420475
- Resource Type:
- Journal Article
- Journal Name:
- International Journal of Radiation Oncology, Biology and Physics
- Additional Journal Information:
- Journal Volume: 90; Journal Issue: 4; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; CATARACTS; CHEMOTHERAPY; CLASSIFICATION; EYES; METASTASES; NEOPLASMS; PATIENTS; PEDIATRICS; PROTON BEAMS; RADIOTHERAPY; SIDE EFFECTS; TOXICITY; VISION
Citation Formats
Mouw, Kent W., Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, Sethi, Roshan V., Yeap, Beow Y., MacDonald, Shannon M., Chen, Yen-Lin E., Tarbell, Nancy J., Yock, Torunn I., Munzenrider, John E., Adams, Judith, Grabowski, Eric, Mukai, Shizuo, and Shih, Helen A., E-mail: hshih@partners.org. Proton Radiation Therapy for the Treatment of Retinoblastoma. United States: N. p., 2014.
Web. doi:10.1016/J.IJROBP.2014.07.031.
Mouw, Kent W., Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, Sethi, Roshan V., Yeap, Beow Y., MacDonald, Shannon M., Chen, Yen-Lin E., Tarbell, Nancy J., Yock, Torunn I., Munzenrider, John E., Adams, Judith, Grabowski, Eric, Mukai, Shizuo, & Shih, Helen A., E-mail: hshih@partners.org. Proton Radiation Therapy for the Treatment of Retinoblastoma. United States. https://doi.org/10.1016/J.IJROBP.2014.07.031
Mouw, Kent W., Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, Sethi, Roshan V., Yeap, Beow Y., MacDonald, Shannon M., Chen, Yen-Lin E., Tarbell, Nancy J., Yock, Torunn I., Munzenrider, John E., Adams, Judith, Grabowski, Eric, Mukai, Shizuo, and Shih, Helen A., E-mail: hshih@partners.org. 2014.
"Proton Radiation Therapy for the Treatment of Retinoblastoma". United States. https://doi.org/10.1016/J.IJROBP.2014.07.031.
@article{osti_22420475,
title = {Proton Radiation Therapy for the Treatment of Retinoblastoma},
author = {Mouw, Kent W. and Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts and Sethi, Roshan V. and Yeap, Beow Y. and MacDonald, Shannon M. and Chen, Yen-Lin E. and Tarbell, Nancy J. and Yock, Torunn I. and Munzenrider, John E. and Adams, Judith and Grabowski, Eric and Mukai, Shizuo and Shih, Helen A., E-mail: hshih@partners.org},
abstractNote = {Purpose: To investigate long-term disease and toxicity outcomes for pediatric retinoblastoma patients treated with proton radiation therapy (PRT). Methods and Materials: This is a retrospective analysis of 49 retinoblastoma patients (60 eyes) treated with PRT between 1986 and 2012. Results: The majority (84%) of patients had bilateral disease, and nearly half (45%) had received prior chemotherapy. At a median follow-up of 8 years (range, 1-24 years), no patients died of retinoblastoma or developed metastatic disease. The post-PRT enucleation rate was low (18%), especially in patients with early-stage disease (11% for patients with International Classification for Intraocular Retinoblastoma [ICIR] stage A-B disease vs 23% for patients with ICIR stage C-D disease). Post-PRT ophthalmologic follow-up was available for 61% of the preserved eyes (30 of 49): 14 of 30 eyes (47%) had 20/40 visual acuity or better, 7 of 30 (23%) had moderate visual acuity (20/40-20/600), and 9 of 30 (30%) had little or no useful vision (worse than 20/600). Twelve of 60 treated eyes (20%) experienced a post-PRT event requiring intervention, with cataracts the most common (4 eyes). No patients developed an in-field second malignancy. Conclusions: Long-term follow-up of retinoblastoma patients treated with PRT demonstrates that PRT can achieve high local control rates, even in advanced cases, and many patients retain useful vision in the treated eye. Treatment-related ocular side effects were uncommon, and no radiation-associated malignancies were observed.},
doi = {10.1016/J.IJROBP.2014.07.031},
url = {https://www.osti.gov/biblio/22420475},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 90,
place = {United States},
year = {Sat Nov 15 00:00:00 EST 2014},
month = {Sat Nov 15 00:00:00 EST 2014}
}