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Title: Impact of Intraluminal Brachytherapy on Survival Outcome for Radiation Therapy for Unresectable Biliary Tract Cancer: A Propensity-Score Matched-Pair Analysis

Purpose: To determine whether adding intraluminal brachytherapy (ILBT) to definitive radiation therapy (RT) for unresectable biliary tract cancer has a positive impact on survival outcome. Methods and Materials: The original cohort comprised 209 patients, including 153 who underwent external beam RT (EBRT) alone and 56 who received both ILBT and EBRT. By matching propensity scores, 56 pairs (112 patients) consisting of 1 patient with and 1 patient without ILBT were selected. They were well balanced in terms of sex, age, performance status, clinical stage, jaundice, and addition of chemotherapy. The impact of ILBT on overall survival (OS), disease-specific survival (DSS), and local control (LC) was investigated. Results: The 2-year OS rates were 31% for the ILBT+ group and 40% for theILBT– group (P=.862). The 2-year DSS rates were 42% for the ILBT+ group and 41% for the ILBT– group (P=.288). The 2-year LC rates were 65% for the ILBT+ group and 35% for the ILBT– group (P=.094). Three of the 4 sensitivity analyses showed a significantly better LC for the ILBT+ group (P=.010, .025, .049), and another showed a marginally better LC (P=.068), and none of the sensitivity analyses showed any statistically significant differences in OS or DSS. Conclusions: In the treatment for unresectable biliary tract cancer,more » the addition of ILBT to RT has no impact on OS or DSS but is associated with better LC. Therefore, the role of ILBT should be addressed by other measures than survival benefit, for example, by less toxicity, prolonged biliary tract patency decreasing the need for further palliative interventions, or patient quality of life.« less
 [1] ;  [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [6] ;  [7] ;  [8] ;  [9] ;  [10] ;  [11] ;  [12] ;  [13] ;  [14] ;  [15] ;  [16] ;  [1] ;  [17] ;  [18]
  1. Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka (Japan)
  2. Department of Radiology, Iwate Medical University, Iwate (Japan)
  3. Department of Radiology, University of Yamanashi, Yamanashi (Japan)
  4. Department of Radiology, Tokyo Medical University, Tokyo (Japan)
  5. Department of Radiation Oncology, Nara Medical University of Medicine, Nara (Japan)
  6. Department of Radiology, Hamamatsu University School of Medicine, Shizuoka (Japan)
  7. Department of Radiation Oncology, Chiba Cancer Center, Chiba (Japan)
  8. Department of Radiology, Jikei University School of Medicine, Tokyo (Japan)
  9. Department of Radiation Oncology, National Cancer Center Hospital, Tokyo (Japan)
  10. Department of Radiology, Kyorin University School of Medicine, Tokyo (Japan)
  11. Department of Radiology, Okayama University, Okayama (Japan)
  12. Department of Radiation Oncology, Tokyo Metropolitan Komagome Hospital, Tokyo (Japan)
  13. Department of Radiology, KKR Sapporo Medical Center, Hokkaido (Japan)
  14. Department of Radiation Oncology, Iwata City Hospital, Shizuoka (Japan)
  15. Department of Radiation Oncology, Kobe City Medical Center General Hospital, Hyogo (Japan)
  16. Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto (Japan)
  17. Department of Radiation Oncology, Yamagata University, Yamagata (Japan)
  18. Department of Radiation Oncology, Kinki University Faculty of Medicine, Osaka (Japan)
Publication Date:
OSTI Identifier:
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 89; Journal Issue: 4; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States