DNAJC6 promotes hepatocellular carcinoma progression through induction of epithelial–mesenchymal transition

Journal Article · Fri Dec 12 00:00:00 EST 2014 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2014.11.011· OSTI ID:22416859

Yang, Tao ^[1]; Li, Xiao-Na ^[2]; Li, Xing-Guang; Li, Ming ^[3]; Gao, Peng-Zhi ^[1]

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1. Hepatobiliary Surgery, The First Hospital of Shijiazhuang City, Shijiazhuang 050011 (China)
2. General Surgery, Sports Science Institute of Hebei Province, Shijiazhuang 050011 (China)
3. General Surgery, The First Hospital of Shijiazhuang City, Shijiazhuang 050011 (China)

Highlights: • DNAJC6 is up-regulated in hepatocellular carcinoma tissues. • DNAJC6 promotes hepatocellular carcinoma cell proliferation and invasion. • DNAJC6 induces epithelial–mesenchymal transition by activating transforming growth factor β signaling. - Abstract: Epithelial–mesenchymal transition (EMT) is a developmental program, which is associated with hepatocellular carcinoma (HCC) development and progression. DNAJC6 (DNA/HSP40 homolog subfamily C member 6) encodes auxilin, which is responsible for juvenile Parkinsonism with phenotypic variability. However, the role of DNAJC6 in HCC development and progression is limited. Here, we report that DNAJC6 is up-regulated in HCC tissues and up-regulation of DNAJC6 expression predicts poor outcome in patients with HCC. Furthermore, overexpression of DNAJC6 enhances the ability for acquisition of mesenchymal traits, enhanced cell proliferation and invasion. DNAJC6 positively regulated expression of EMT-related transcription factor, also activating transforming growth factor β (TGF-β) pathway to contribute to EMT. Our findings demonstrated an important function of DNAJC6 in the progression of HCC by induction of EMT, and they implicate DNAJC6 as a marker of poor outcome in HCC.

• OSTI ID: 22416859
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 455, Issue 3-4; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANIMAL TISSUES
CELL PROLIFERATION
DNA
GROWTH FACTORS
HEPATOMAS
JUVENILES
PATIENTS
TRANSCRIPTION FACTORS