The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells
- Affichem, Toulouse (France)
- Department of Public Health and Caring Sciences, Uppsala University, Uppsala (Sweden)
- Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Uppsala (Sweden)
- INSERM UMR 1037, Team “Sterol Metabolism and Therapeutic Innovations in Oncology”, Cancer Research Center of Toulouse, F-31052 Toulouse (France)
Highlights: • Dendrogenin A and B are new aminoalkyl oxysterols. • Dendrogenins stimulated neural stem cells proliferation. • Dendrogenins induce neuronal outgrowth from neurospheres. • Dendrogenins provide new therapeutic options for neurodegenerative disorders. - Abstract: Dendrogenin A (DDA) and dendrogenin B (DDB) are new aminoalkyl oxysterols which display re-differentiation of tumor cells of neuronal origin at nanomolar concentrations. We analyzed the influence of dendrogenins on adult mice neural stem cell proliferation, sphere formation and differentiation. DDA and DDB were found to have potent proliferative effects in neural stem cells. Additionally, they induce neuronal outgrowth from neurospheres during in vitro cultivation. Taken together, our results demonstrate a novel role for dendrogenins A and B in neural stem cell proliferation and differentiation which further increases their likely importance to compensate for neuronal cell loss in the brain.
- OSTI ID:
- 22416368
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 446, Issue 3; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Valproic acid promotes the neuronal differentiation of spiral ganglion neural stem cells with robust axonal growth
Microglia support neural stem cell maintenance and growth