An enzyme logic bioprotonic transducer
- Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195-2120 (United States)
Translating ionic currents into measureable electronic signals is essential for the integration of bioelectronic devices with biological systems. We demonstrate the use of a Pd/PdH{sub x} electrode as a bioprotonic transducer that connects H{sup +} currents in solution into an electronic signal. This transducer exploits the reversible formation of PdH{sub x} in solution according to PdH↔Pd + H{sup +} + e{sup −}, and the dependence of this formation on solution pH and applied potential. We integrate the protonic transducer with glucose dehydrogenase as an enzymatic AND gate for glucose and NAD{sup +}. PdH{sub x} formation and associated electronic current monitors the output drop in pH, thus transducing a biological function into a measurable electronic output.
- OSTI ID:
- 22415239
- Journal Information:
- APL materials, Vol. 3, Issue 1; Other Information: (c) 2014 Author(s); Country of input: International Atomic Energy Agency (IAEA); ISSN 2166-532X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin
Proton mediated control of biochemical reactions with bioelectronic pH modulation