Fiber-optic detector for real time dosimetry of a micro-planar x-ray beam

Belley, Matthew D.; Stanton, Ian N.; Langloss, Brian W.; Therien, Michael J.; Hadsell, Mike; Ger, Rachel; Lu, Jianping; Zhou, Otto; Chang, Sha X.

doi:10.1118/1.4915078

Title: Fiber-optic detector for real time dosimetry of a micro-planar x-ray beam

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Abstract

Purpose: Here, the authors describe a dosimetry measurement technique for microbeam radiation therapy using a nanoparticle-terminated fiber-optic dosimeter (nano-FOD). Methods: The nano-FOD was placed in the center of a 2 cm diameter mouse phantom to measure the deep tissue dose and lateral beam profile of a planar x-ray microbeam. Results: The continuous dose rate at the x-ray microbeam peak measured with the nano-FOD was 1.91 ± 0.06 cGy s{sup −1}, a value 2.7% higher than that determined via radiochromic film measurements (1.86 ± 0.15 cGy s{sup −1}). The nano-FOD-determined lateral beam full-width half max value of 420 μm exceeded that measured using radiochromic film (320 μm). Due to the 8° angle of the collimated microbeam and resulting volumetric effects within the scintillator, the profile measurements reported here are estimated to achieve a resolution of ∼0.1 mm; however, for a beam angle of 0°, the theoretical resolution would approach the thickness of the scintillator (∼0.01 mm). Conclusions: This work provides proof-of-concept data and demonstrates that the novel nano-FOD device can be used to perform real-time dosimetry in microbeam radiation therapy to measure the continuous dose rate at the x-ray microbeam peak as well as the lateral beam shape.

Authors:

Belley, Matthew D. ^[1]; Stanton, Ian N.; Langloss, Brian W.; Therien, Michael J. ^[2]; Hadsell, Mike; Ger, Rachel; Lu, Jianping ^[3]; Zhou, Otto ^[4]; Chang, Sha X. ^[3]

Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27705 and Duke Radiation Dosimetry Laboratory, Duke University Medical Center, Durham, North Carolina 27710 (United States)
Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708 (United States)
Department of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599 (United States)
Department of Physics and Astronomy, University of North Carolina, Chapel Hill, North Carolina 27599 and UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599 (United States)

Publication Date:: Wed Apr 15 00:00:00 EDT 2015

OSTI Identifier:: 22413522

Resource Type:: Journal Article

Journal Name:: Medical Physics

Additional Journal Information:: Journal Volume: 42; Journal Issue: 4; Other Information: (c) 2015 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; BEAM PROFILES; DOSEMETERS; DOSIMETRY; MICE; PHANTOMS; RADIATION DOSES; RADIOTHERAPY; X RADIATION

Citation Formats


                    Belley, Matthew D., Stanton, Ian N., Langloss, Brian W., Therien, Michael J., Hadsell, Mike, Ger, Rachel, Lu, Jianping, Zhou, Otto, Chang, Sha X., Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599, Yoshizumi, Terry T., E-mail: terry.yoshizumi@duke.edu, Duke Radiation Dosimetry Laboratory, Duke University Medical Center, Durham, North Carolina 27710, and and Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710. Fiber-optic detector for real time dosimetry of a micro-planar x-ray beam.  United States: N. p., 2015. 
        Web.  doi:10.1118/1.4915078.

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                    Belley, Matthew D., Stanton, Ian N., Langloss, Brian W., Therien, Michael J., Hadsell, Mike, Ger, Rachel, Lu, Jianping, Zhou, Otto, Chang, Sha X., Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599, Yoshizumi, Terry T., E-mail: terry.yoshizumi@duke.edu, Duke Radiation Dosimetry Laboratory, Duke University Medical Center, Durham, North Carolina 27710, & and Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710. Fiber-optic detector for real time dosimetry of a micro-planar x-ray beam.  United States.  https://doi.org/10.1118/1.4915078

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                    Belley, Matthew D., Stanton, Ian N., Langloss, Brian W., Therien, Michael J., Hadsell, Mike, Ger, Rachel, Lu, Jianping, Zhou, Otto, Chang, Sha X., Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599, Yoshizumi, Terry T., E-mail: terry.yoshizumi@duke.edu, Duke Radiation Dosimetry Laboratory, Duke University Medical Center, Durham, North Carolina 27710, and and Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710. 2015.  
        "Fiber-optic detector for real time dosimetry of a micro-planar x-ray beam".  United States.  https://doi.org/10.1118/1.4915078.

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@article{osti_22413522,

  title        = {Fiber-optic detector for real time dosimetry of a micro-planar x-ray beam},

  author       = {Belley, Matthew D. and Stanton, Ian N. and Langloss, Brian W. and Therien, Michael J. and Hadsell, Mike and Ger, Rachel and Lu, Jianping and Zhou, Otto and Chang, Sha X. and Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599 and UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599 and Yoshizumi, Terry T., E-mail: terry.yoshizumi@duke.edu and Duke Radiation Dosimetry Laboratory, Duke University Medical Center, Durham, North Carolina 27710 and and Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710},

  abstractNote = {Purpose: Here, the authors describe a dosimetry measurement technique for microbeam radiation therapy using a nanoparticle-terminated fiber-optic dosimeter (nano-FOD). Methods: The nano-FOD was placed in the center of a 2 cm diameter mouse phantom to measure the deep tissue dose and lateral beam profile of a planar x-ray microbeam. Results: The continuous dose rate at the x-ray microbeam peak measured with the nano-FOD was 1.91 ± 0.06 cGy s{sup −1}, a value 2.7% higher than that determined via radiochromic film measurements (1.86 ± 0.15 cGy s{sup −1}). The nano-FOD-determined lateral beam full-width half max value of 420 μm exceeded that measured using radiochromic film (320 μm). Due to the 8° angle of the collimated microbeam and resulting volumetric effects within the scintillator, the profile measurements reported here are estimated to achieve a resolution of ∼0.1 mm; however, for a beam angle of 0°, the theoretical resolution would approach the thickness of the scintillator (∼0.01 mm). Conclusions: This work provides proof-of-concept data and demonstrates that the novel nano-FOD device can be used to perform real-time dosimetry in microbeam radiation therapy to measure the continuous dose rate at the x-ray microbeam peak as well as the lateral beam shape.},

  doi          = {10.1118/1.4915078},

  url          = {https://www.osti.gov/biblio/22413522},
  journal      = {Medical Physics},

  issn         = {0094-2405},

  number       = 4,

  volume       = 42,

  place        = {United States},

  year         = {Wed Apr 15 00:00:00 EDT 2015},

  month        = {Wed Apr 15 00:00:00 EDT 2015}

}

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