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Title: WE-G-18C-06: Is Diaphragm Motion a Good Surrogate for Liver Tumor Motion?

Abstract

Purpose: To investigate whether diaphragm motion is a good surrogate for liver tumor motion by comparing their motion trajectories obtained from cine-MRI. Methods: Fourteen patients with hepatocellular carcinoma (10/14) or liver metastases (4/14) undergoing radiation therapy were included in this study. All patients underwent single-slice 2D cine-MRI simulations across the center of the tumor in three orthogonal planes. Tumor and diaphragm motion trajectories in the superior-inferior (SI), anteriorposterior (AP), and medial-lateral (ML) directions were obtained using the normalized cross-correlation based tracking technique. Agreement between tumor and diaphragm motions was assessed by calculating the phase difference percentage (PDP), intra-class correlation coefficient (ICC), Bland-Altman analysis (Diffs) and paired t-test. The distance (D) between tumor and tracked diaphragm area was analyzed to understand its impact on the correlation between tumor and diaphragm motions. Results: Of all patients, the means (±standard deviations) of PDP were 7.1 (±1.1)%, 4.5 (±0.5)% and 17.5 (±4.5)% in the SI, AP and ML directions, respectively. The means of ICC were 0.98 (±0.02), 0.97 (±0.02), and 0.08 (±0.06) in the SI, AP and ML directions, respectively. The Diffs were 2.8 (±1.4) mm, 2.4 (±1.1) mm, and 2.2 (±0.5) mm in the SI, AP and ML directions, respectively. The p-values derivedmore » from the paired t-test were < 0.02 in SI and AP directions, whereas were > 0.58 in ML direction primarily due to the small motion in ML direction. Tumor and diaphragmatic motion had high concordance when the distance between the tumor and tracked diaphragm areas was small. Conclusion: Preliminary results showed that liver tumor motion had good correlations with diaphragm motion in the SI and AP directions, indicating diaphragm motion in the SI and AP directions could potentially be a reliable surrogate for liver tumor motion. NIH (1R21CA165384-01A1), Golfers Against Cancer (GAC) Foundation, The China Scholarship Council (CSC)« less

Authors:
 [1]; ; ; ; ;  [1];  [2];  [3]
  1. Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)
  2. School of Information Science and Engineering, Shandong University, Jinan, Shandong (China)
  3. Department of Radiology, Duke University Medical Center, Durham, NC (United States)
Publication Date:
OSTI Identifier:
22409777
Resource Type:
Journal Article
Journal Name:
Medical Physics
Additional Journal Information:
Journal Volume: 41; Journal Issue: 6; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; COMPARATIVE EVALUATIONS; CORRELATIONS; DIAPHRAGM; HEPATOMAS; LIVER; METASTASES; MOTION; NMR IMAGING; PATIENTS; RADIOTHERAPY

Citation Formats

Yang, J, School of Information Science and Engineering, Shandong University, Jinan, Shandong, Cai, J, Zheng, C, Czito, B, Palta, M, Yin, F, Wang, H, and Bashir, M. WE-G-18C-06: Is Diaphragm Motion a Good Surrogate for Liver Tumor Motion?. United States: N. p., 2014. Web. doi:10.1118/1.4889525.
Yang, J, School of Information Science and Engineering, Shandong University, Jinan, Shandong, Cai, J, Zheng, C, Czito, B, Palta, M, Yin, F, Wang, H, & Bashir, M. WE-G-18C-06: Is Diaphragm Motion a Good Surrogate for Liver Tumor Motion?. United States. https://doi.org/10.1118/1.4889525
Yang, J, School of Information Science and Engineering, Shandong University, Jinan, Shandong, Cai, J, Zheng, C, Czito, B, Palta, M, Yin, F, Wang, H, and Bashir, M. 2014. "WE-G-18C-06: Is Diaphragm Motion a Good Surrogate for Liver Tumor Motion?". United States. https://doi.org/10.1118/1.4889525.
@article{osti_22409777,
title = {WE-G-18C-06: Is Diaphragm Motion a Good Surrogate for Liver Tumor Motion?},
author = {Yang, J and School of Information Science and Engineering, Shandong University, Jinan, Shandong and Cai, J and Zheng, C and Czito, B and Palta, M and Yin, F and Wang, H and Bashir, M},
abstractNote = {Purpose: To investigate whether diaphragm motion is a good surrogate for liver tumor motion by comparing their motion trajectories obtained from cine-MRI. Methods: Fourteen patients with hepatocellular carcinoma (10/14) or liver metastases (4/14) undergoing radiation therapy were included in this study. All patients underwent single-slice 2D cine-MRI simulations across the center of the tumor in three orthogonal planes. Tumor and diaphragm motion trajectories in the superior-inferior (SI), anteriorposterior (AP), and medial-lateral (ML) directions were obtained using the normalized cross-correlation based tracking technique. Agreement between tumor and diaphragm motions was assessed by calculating the phase difference percentage (PDP), intra-class correlation coefficient (ICC), Bland-Altman analysis (Diffs) and paired t-test. The distance (D) between tumor and tracked diaphragm area was analyzed to understand its impact on the correlation between tumor and diaphragm motions. Results: Of all patients, the means (±standard deviations) of PDP were 7.1 (±1.1)%, 4.5 (±0.5)% and 17.5 (±4.5)% in the SI, AP and ML directions, respectively. The means of ICC were 0.98 (±0.02), 0.97 (±0.02), and 0.08 (±0.06) in the SI, AP and ML directions, respectively. The Diffs were 2.8 (±1.4) mm, 2.4 (±1.1) mm, and 2.2 (±0.5) mm in the SI, AP and ML directions, respectively. The p-values derived from the paired t-test were < 0.02 in SI and AP directions, whereas were > 0.58 in ML direction primarily due to the small motion in ML direction. Tumor and diaphragmatic motion had high concordance when the distance between the tumor and tracked diaphragm areas was small. Conclusion: Preliminary results showed that liver tumor motion had good correlations with diaphragm motion in the SI and AP directions, indicating diaphragm motion in the SI and AP directions could potentially be a reliable surrogate for liver tumor motion. NIH (1R21CA165384-01A1), Golfers Against Cancer (GAC) Foundation, The China Scholarship Council (CSC)},
doi = {10.1118/1.4889525},
url = {https://www.osti.gov/biblio/22409777}, journal = {Medical Physics},
issn = {0094-2405},
number = 6,
volume = 41,
place = {United States},
year = {Sun Jun 15 00:00:00 EDT 2014},
month = {Sun Jun 15 00:00:00 EDT 2014}
}