Multimodal diagnosis and visualisation of oncologic pathologies

Journal Article · Sun Aug 31 00:00:00 EDT 2014 · Quantum Electronics (Woodbury, N.Y.)

DOI:https://doi.org/10.1070/QE2014V044N08ABEH015545· OSTI ID:22395821

Zakharov, V P; Bratchenko, I A; Myakinin, O O; Artemyev, D N; Kornilin, D V ^[1]; Kozlov, S V; Moryatov, A A ^[2]

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1. S.P. Korolev Samara State Aerospace University, Samara (Russian Federation)
2. Samara State Medical University, Samara (Russian Federation)

The combined application of optical coherence tomography, Raman and autofluorescence spectroscopy of biotissues for the analysis of human malignant neoplasms is demonstrated. Rapid investigation of vast biotissue regions (at the scale of entire organs) is possible using the autofluorescence response. After selection of possible zones of pathologies one can visualise the neoplasm topology in the zone of interest with micron precision by using optical coherence tomography. In the case of suspecting the malignancy the analysis of the biotissue Raman spectrum is carried out that allows identification of the neoplasm type with the sensitivity and specificity ∼85%. An experimental scheme is proposed with the combined use of the abovementioned methods, which is a prototype of the medical system for complex analysis of neoplasms. (laser biophotonics)

• OSTI ID: 22395821
• Journal Information: Quantum Electronics (Woodbury, N.Y.), Vol. 44, Issue 8; Other Information: Country of input: International Atomic Energy Agency (IAEA); ISSN 1063-7818
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
DIAGNOSIS
FLUORESCENCE
NEOPLASMS
ORGANS
PATHOLOGY
RAMAN SPECTRA
SENSITIVITY
SPECIFICITY
TOMOGRAPHY