Inhibition of brain tumor cell proliferation by alternating electric fields

Journal Article · Mon Nov 17 00:00:00 EST 2014 · Applied Physics Letters

DOI:https://doi.org/10.1063/1.4902112· OSTI ID:22392044

Jeong, Hyesun; Oh, Seung-ick; Hong, Sunghoi ^[1]; Sung, Jiwon; Jeong, Seonghoon; Yoon, Myonggeun ^[2]; Koh, Eui Kwan ^[3]

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1. School of Biosystem and Biomedical Science, Korea University, Seoul 136-703 (Korea, Republic of)
2. Department of Bio-convergence Engineering, Korea University, Seoul 136-703 (Korea, Republic of)
3. Seoul Center, Korea Basic Science Institute, Seoul 136-713 (Korea, Republic of)

This study was designed to investigate the mechanism by which electric fields affect cell function, and to determine the optimal conditions for electric field inhibition of cancer cell proliferation. Low-intensity (<2 V/cm) and intermediate-frequency (100–300 kHz) alternating electric fields were applied to glioblastoma cell lines. These electric fields inhibited cell proliferation by inducing cell cycle arrest and abnormal mitosis due to the malformation of microtubules. These effects were significantly dependent on the intensity and frequency of applied electric fields.

• OSTI ID: 22392044
• Journal Information: Applied Physics Letters, Vol. 105, Issue 20; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0003-6951
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BRAIN
CELL PROLIFERATION
ELECTRIC FIELDS
GLIOMAS
INHIBITION
KHZ RANGE 100-1000
MALFORMATIONS
MICROTUBULES
TUMOR CELLS