Detection of saliva-range glucose concentrations using organic thin-film transistors

Journal Article · Mon Jul 28 00:00:00 EDT 2014 · Applied Physics Letters

DOI:https://doi.org/10.1063/1.4892012· OSTI ID:22311222

Elkington, D.; Belcher, W. J.; Dastoor, P. C.; Zhou, X. J. ^[1]

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1. Centre for Organic Electronics, University of Newcastle, Callaghan, New South Wales 2308 (Australia)

We describe the development of a glucose sensor through direct incorporation of an enzyme (glucose oxidase) into the gate of an organic thin film transistor (OTFT). We show that glucose diffusion is the key determinant of the device response time and present a mechanism of glucose sensing in these devices that involves protonic doping of the transistor channel via enzymatic oxidation of glucose. The integrated OTFT sensor is sensitive across 4 decades of glucose concentration; a range that encompasses both the blood and salivary glucose concentration levels. As such, this work acts as a proof-of-concept for low-cost printed biosensors for salivary glucose.

• OSTI ID: 22311222
• Journal Information: Applied Physics Letters, Vol. 105, Issue 4; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0003-6951
• Country of Publication: United States
• Language: English

Related Subjects

75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
BLOOD
CONCENTRATION RATIO
DETECTION
DIFFUSION
EQUIPMENT
GLUCOSE
ORGANIC SEMICONDUCTORS
OXIDASES
OXIDATION
SALIVA
SENSORS
THIN FILMS
TRANSISTORS