Dynamic disorder and the energetic costs of information transduction
Journal Article
·
· Journal of Chemical Physics
- Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142 (United States)
We study a model of dynamic disorder relevant for signal transduction pathways in which enzymatic reaction rates fluctuate over several orders of magnitude. For the simple networks we consider, dynamic disorder drives the system far from equilibrium and imposes an energetic burden for high fidelity signaling capability. We study how the dynamics of the underlying stochastic behavior in the reaction rate process is related to the energetic cost of transmitting information through the network.
- OSTI ID:
- 22308762
- Journal Information:
- Journal of Chemical Physics, Vol. 141, Issue 1; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0021-9606
- Country of Publication:
- United States
- Language:
- English
Similar Records
The Goldbeter-Koshland Switch in the First-Order Region and Its Response to Dynamic Disorder
Transitions in genetic toggle switches driven by dynamic disorder in rate coefficients
AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems
Journal Article
·
Wed May 14 00:00:00 EDT 2008
· PLoS ONE
·
OSTI ID:22308762
Transitions in genetic toggle switches driven by dynamic disorder in rate coefficients
Journal Article
·
Sat May 07 00:00:00 EDT 2016
· Journal of Chemical Physics
·
OSTI ID:22308762
AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems
Journal Article
·
Thu May 07 00:00:00 EDT 2015
· Entropy
·
OSTI ID:22308762