Interactive Decision-Support Tool for Risk-Based Radiation Therapy Plan Comparison for Hodgkin Lymphoma

Brodin, N. Patrik; Aznar, Marianne C.; Vogelius, Ivan R.; Petersen, Peter M.; Bentzen, Søren M.; Specht, Lena

doi:10.1016/J.IJROBP.2013.10.028

Title: Interactive Decision-Support Tool for Risk-Based Radiation Therapy Plan Comparison for Hodgkin Lymphoma

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Abstract

Purpose: To present a novel tool that allows quantitative estimation and visualization of the risk of various relevant normal tissue endpoints to aid in treatment plan comparison and clinical decision making in radiation therapy (RT) planning for Hodgkin lymphoma (HL). Methods and Materials: A decision-support tool for risk-based, individualized treatment plan comparison is presented. The tool displays dose–response relationships, derived from published clinical data, for a number of relevant side effects and thereby provides direct visualization of the trade-off between these endpoints. The Quantitative Analyses of Normal Tissue Effects in the Clinic reports were applied, complemented with newer data where available. A “relevance score” was assigned to each data source, reflecting how relevant the input data are to current RT for HL. Results: The tool is applied to visualize the local steepness of dose–response curves to drive the reoptimization of a volumetric modulated arc therapy treatment plan for an HL patient with head-and-neck involvement. We also use this decision-support tool to visualize and quantitatively evaluate the trade-off between a 3-dimensional conformal RT plan and a volumetric modulated arc therapy plan for a patient with mediastinal HL. Conclusion: This multiple-endpoint decision-support tool provides quantitative risk estimates to supplement the clinical judgmentmore »« less

Authors:

Brodin, N. Patrik ^[1]; Aznar, Marianne C. ^[2]; Vogelius, Ivan R. ^[2]; Petersen, Peter M. ^[2]; Bentzen, Søren M. ^[2]; Specht, Lena ^[2]

Department of Radiation Oncology, Albert Einstein College of Medicine of Yeshiva University, New York, New York (United States)
Department of Radiation Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen (Denmark)

Publication Date:: Sat Feb 01 00:00:00 EST 2014

OSTI Identifier:: 22283361

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 88; Journal Issue: 2; Other Information: Copyright (c) 2014 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; DECISION MAKING; HAZARDS; LYMPHOMAS; PLANNING; RADIOTHERAPY; SIDE EFFECTS; THREE-DIMENSIONAL CALCULATIONS

Citation Formats


                    Brodin, N. Patrik, Maraldo, Maja V., E-mail: dra.maraldo@gmail.com, Aznar, Marianne C., Niels Bohr Institute, Faculty of Sciences, University of Copenhagen, Copenhagen, Vogelius, Ivan R., Petersen, Peter M., Department of Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen, Department of Hematology, Rigshospitalet, Faculty of Sciences, University of Copenhagen, Copenhagen, Bentzen, Søren M., Department of Human Oncology, University of Wisconsin Medical School, Madison, Wisconsin, Specht, Lena, Department of Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen, and Department of Hematology, Rigshospitalet, Faculty of Sciences, University of Copenhagen, Copenhagen. Interactive Decision-Support Tool for Risk-Based Radiation Therapy Plan Comparison for Hodgkin Lymphoma.  United States: N. p., 2014. 
        Web.  doi:10.1016/J.IJROBP.2013.10.028.

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                    Brodin, N. Patrik, Maraldo, Maja V., E-mail: dra.maraldo@gmail.com, Aznar, Marianne C., Niels Bohr Institute, Faculty of Sciences, University of Copenhagen, Copenhagen, Vogelius, Ivan R., Petersen, Peter M., Department of Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen, Department of Hematology, Rigshospitalet, Faculty of Sciences, University of Copenhagen, Copenhagen, Bentzen, Søren M., Department of Human Oncology, University of Wisconsin Medical School, Madison, Wisconsin, Specht, Lena, Department of Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen, & Department of Hematology, Rigshospitalet, Faculty of Sciences, University of Copenhagen, Copenhagen. Interactive Decision-Support Tool for Risk-Based Radiation Therapy Plan Comparison for Hodgkin Lymphoma.  United States.  https://doi.org/10.1016/J.IJROBP.2013.10.028

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                    Brodin, N. Patrik, Maraldo, Maja V., E-mail: dra.maraldo@gmail.com, Aznar, Marianne C., Niels Bohr Institute, Faculty of Sciences, University of Copenhagen, Copenhagen, Vogelius, Ivan R., Petersen, Peter M., Department of Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen, Department of Hematology, Rigshospitalet, Faculty of Sciences, University of Copenhagen, Copenhagen, Bentzen, Søren M., Department of Human Oncology, University of Wisconsin Medical School, Madison, Wisconsin, Specht, Lena, Department of Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen, and Department of Hematology, Rigshospitalet, Faculty of Sciences, University of Copenhagen, Copenhagen. 2014.  
        "Interactive Decision-Support Tool for Risk-Based Radiation Therapy Plan Comparison for Hodgkin Lymphoma".  United States.  https://doi.org/10.1016/J.IJROBP.2013.10.028.

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@article{osti_22283361,

  title        = {Interactive Decision-Support Tool for Risk-Based Radiation Therapy Plan Comparison for Hodgkin Lymphoma},

  author       = {Brodin, N. Patrik and Maraldo, Maja V., E-mail: dra.maraldo@gmail.com and Aznar, Marianne C. and Niels Bohr Institute, Faculty of Sciences, University of Copenhagen, Copenhagen and Vogelius, Ivan R. and Petersen, Peter M. and Department of Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen and Department of Hematology, Rigshospitalet, Faculty of Sciences, University of Copenhagen, Copenhagen and Bentzen, Søren M. and Department of Human Oncology, University of Wisconsin Medical School, Madison, Wisconsin and Specht, Lena and Department of Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen and Department of Hematology, Rigshospitalet, Faculty of Sciences, University of Copenhagen, Copenhagen},

  abstractNote = {Purpose: To present a novel tool that allows quantitative estimation and visualization of the risk of various relevant normal tissue endpoints to aid in treatment plan comparison and clinical decision making in radiation therapy (RT) planning for Hodgkin lymphoma (HL). Methods and Materials: A decision-support tool for risk-based, individualized treatment plan comparison is presented. The tool displays dose–response relationships, derived from published clinical data, for a number of relevant side effects and thereby provides direct visualization of the trade-off between these endpoints. The Quantitative Analyses of Normal Tissue Effects in the Clinic reports were applied, complemented with newer data where available. A “relevance score” was assigned to each data source, reflecting how relevant the input data are to current RT for HL. Results: The tool is applied to visualize the local steepness of dose–response curves to drive the reoptimization of a volumetric modulated arc therapy treatment plan for an HL patient with head-and-neck involvement. We also use this decision-support tool to visualize and quantitatively evaluate the trade-off between a 3-dimensional conformal RT plan and a volumetric modulated arc therapy plan for a patient with mediastinal HL. Conclusion: This multiple-endpoint decision-support tool provides quantitative risk estimates to supplement the clinical judgment of the radiation oncologist when comparing different RT options.},

  doi          = {10.1016/J.IJROBP.2013.10.028},

  url          = {https://www.osti.gov/biblio/22283361},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 2,

  volume       = 88,

  place        = {United States},

  year         = {Sat Feb 01 00:00:00 EST 2014},

  month        = {Sat Feb 01 00:00:00 EST 2014}

}

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