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Title: Retrospective Cohort Study of Bronchial Doses and Radiation-Induced Atelectasis After Stereotactic Body Radiation Therapy of Lung Tumors Located Close to the Bronchial Tree

Purpose: To evaluate the dose–response relationship between radiation-induced atelectasis after stereotactic body radiation therapy (SBRT) and bronchial dose. Methods and Materials: Seventy-four patients treated with SBRT for tumors close to main, lobar, or segmental bronchi were selected. The association between incidence of atelectasis and bronchial dose parameters (maximum point-dose and minimum dose to the high-dose bronchial volume [ranging from 0.1 cm{sup 3} up to 2.0 cm{sup 3}]) was statistically evaluated with survival analysis models. Results: Prescribed doses varied between 4 and 20 Gy per fraction in 2-5 fractions. Eighteen patients (24.3%) developed atelectasis considered to be radiation-induced. Statistical analysis showed a significant correlation between the incidence of radiation-induced atelectasis and minimum dose to the high-dose bronchial volumes, of which 0.1 cm{sup 3} (D{sub 0.1cm3}) was used for further analysis. The median value of D{sub 0.1cm3} (α/β = 3 Gy) was EQD{sub 2,LQ} = 147 Gy{sub 3} (range, 20-293 Gy{sub 3}). For patients who developed atelectasis the median value was EQD{sub 2,LQ} = 210 Gy{sub 3}, and for patients who did not develop atelectasis, EQD{sub 2,LQ} = 105 Gy{sub 3}. Median time from treatment to development of atelectasis was 8.0 months (range, 1.1-30.1 months). Conclusion: In this retrospective study a significantmore » dose–response relationship between the incidence of atelectasis and the dose to the high-dose volume of the bronchi is shown.« less
 [1] ;  [2] ;  [3] ; ;  [4] ;  [2] ;  [5] ;  [1] ;  [2] ;  [5] ;  [6] ;  [7] ;  [4] ;  [2] ;  [1] ;  [2]
  1. Department of Medical Physics, Karolinska University Hospital, Stockholm (Sweden)
  2. (Sweden)
  3. Department of Oncology, Sahlgrenska University Hospital, Gothenburg (Sweden)
  4. Department of Oncology, Radiumhemmet, Karolinska University Hospital, Stockholm (Sweden)
  5. Department of Radiation Physics, Sahlgrenska University Hospital, Gothenburg (Sweden)
  6. Statistical Research Group, Mathematical Statistics, Stockholm University, Stockholm (Sweden)
  7. Physics Department, Clatterbridge Cancer Centre, Wirral (United Kingdom)
Publication Date:
OSTI Identifier:
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 87; Journal Issue: 3; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States