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Title: Use of EORTC Target Definition Guidelines for Dose-Intensified Salvage Radiation Therapy for Recurrent Prostate Cancer: Results of the Quality Assurance Program of the Randomized Trial SAKK 09/10

Purpose: Different international target volume delineation guidelines exist and different treatment techniques are available for salvage radiation therapy (RT) for recurrent prostate cancer, but less is known regarding their respective applicability in clinical practice. Methods and Materials: A randomized phase III trial testing 64 Gy vs 70 Gy salvage RT was accompanied by an intense quality assurance program including a site-specific and study-specific questionnaire and a dummy run (DR). Target volume delineation was performed according to the European Organisation for the Research and Treatment of Cancer guidelines, and a DR-based treatment plan was established for 70 Gy. Major and minor protocol deviations were noted, interobserver agreement of delineated target contours was assessed, and dose-volume histogram (DVH) parameters of different treatment techniques were compared. Results: Thirty European centers participated, 43% of which were using 3-dimensional conformal RT (3D-CRT), with the remaining centers using intensity modulated RT (IMRT) or volumetric modulated arc technique (VMAT). The first submitted version of the DR contained major deviations in 21 of 30 (70%) centers, mostly caused by inappropriately defined or lack of prostate bed (PB). All but 5 centers completed the DR successfully with their second submitted version. The interobserver agreement of the PB was moderatemore » and was improved by the DR review, as indicated by an increased κ value (0.59 vs 0.55), mean sensitivity (0.64 vs 0.58), volume of total agreement (3.9 vs 3.3 cm{sup 3}), and decrease in the union volume (79.3 vs 84.2 cm{sup 3}). Rectal and bladder wall DVH parameters of IMRT and VMAT vs 3D-CRT plans were not significantly different. Conclusions: The interobserver agreement of PB delineation was moderate but was improved by the DR. Major deviations could be identified for the majority of centers. The DR has improved the acquaintance of the participating centers with the trial protocol.« less
 [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [6] ;  [7] ;  [8] ;  [9] ;  [10] ;  [11] ;  [12] ;  [13] ;  [14] ;  [15] ;  [1] ;  [16] ;  [17] ;  [18] ;  [1] more »; « less
  1. Department of Radiation Oncology and Division of Medical Radiation Physics, Bern University Hospital (Switzerland)
  2. Department of Radiation Oncology Kantonsspital Luzern (Switzerland)
  3. University Hospital Dresden (Germany)
  4. University Hospital Rostock (Germany)
  5. University Hospital Tübingen (Germany)
  6. University Hospital Zürich (Switzerland)
  7. University Hospital Basel (Switzerland)
  8. Stadtspital Triemli, Zürich (Switzerland)
  9. University Hospital Würzburg (Germany)
  10. Kantonsspital Graubünden, Chur (Switzerland)
  11. Istituto Oncologico della Svizzera Italiana, Bellinzona (Switzerland)
  12. Kantonsspital St. Gallen (Switzerland)
  13. Kantonsspital Aarau (Switzerland)
  14. Kantonsspital Münsterlingen (Switzerland)
  15. Hirslanden Hospital Group, Zürich (Switzerland)
  16. Ghent University Hospital (Belgium)
  17. Charité University Medicine, Berlin (Germany)
  18. Swiss Group for Clinical Cancer Research, Coordinating Center, Bern (Switzerland)
Publication Date:
OSTI Identifier:
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 87; Journal Issue: 3; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States