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Title: The Effect of Radiation Timing on Patients With High-Risk Features of Parameningeal Rhabdomyosarcoma: An Analysis of IRS-IV and D9803

Purpose: Radiation therapy remains an essential treatment for patients with parameningeal rhabdomyosarcoma (PMRMS), and early radiation therapy may improve local control for patients with intracranial extension (ICE). Methods and Materials: To address the role of radiation therapy timing in PMRMS in the current era, we reviewed the outcome from 2 recent clinical trials for intermediate-risk RMS: Intergroup Rhabdomyosarcoma Study (IRS)-IV and Children's Oncology Group (COG) D9803. The PMRMS patients on IRS-IV with any high-risk features (cranial nerve palsy [CNP], cranial base bony erosion [CBBE], or ICE) were treated immediately at day 0, and PMRMS patients without any of these 3 features received week 6-9 radiation therapy. The D9803 PMRMS patients with ICE received day 0 X-Ray Therapy (XRT) as well; however, those with either CNP or CBBE had XRT at week 12. Results: Compared with the 198 PMRMS patients from IRS-IV, the 192 PMRMS patients from D9803 had no difference (P<.05) in 5-year local failure (19% vs 19%), failure-free-survival (70% vs 67%), or overall survival (75% vs 73%) in aggregate. The 5-year local failure rates by subset did not differ when patients were classified as having no risk features (None, 15% vs 19%, P=.25), cranial nerve palsy/cranial base of skullmore » erosion (CNP/CBBE, 15% vs 28%, P=.22), or intracranial extension (ICE, 21% vs 15%, P=.27). The D9083 patients were more likely to have received initial staging by magnetic resonance imaging (71% vs 53%). Conclusions: These data support that a delay in radiation therapy for high-risk PMRMS features of CNP/CBBE does not compromise clinical outcomes.« less
 [1] ;  [2] ;  [3] ; ;  [4] ;  [5] ;  [6] ;  [7] ;  [8]
  1. Kosair Children's Hospital and Brain Tumor Center, Louisville, Kentucky (United States)
  2. Division of Hematology/Oncology, Seattle Children's Hospital, and Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington (United States)
  3. Department of Radiation Oncology, Stanford University Medical Center, Stanford, California (United States)
  4. University of Nebraska Medical Center, Omaha, Nebraska (United States)
  5. Quality Assurance Review Center, Providence, Rhode Island and Seattle, Washington (United States)
  6. Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)
  7. Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota (United States)
  8. Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri (United States)
Publication Date:
OSTI Identifier:
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 87; Journal Issue: 3; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States