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Title: Feasibility study of volumetric modulated arc therapy with constant dose rate for endometrial cancer

Abstract

To investigate the feasibility, efficiency, and delivery accuracy of volumetric modulated arc therapy with constant dose rate (VMAT-CDR) for whole-pelvic radiotherapy (WPRT) of endometrial cancer. The nine-field intensity-modulated radiotherapy (IMRT), VMAT with variable dose-rate (VMAT-VDR), and VMAT-CDR plans were created for 9 patients with endometrial cancer undergoing WPRT. The dose distribution of planning target volume (PTV), organs at risk (OARs), and normal tissue (NT) were compared. The monitor units (MUs) and treatment delivery time were also evaluated. For each VMAT-CDR plan, a dry run was performed to assess the dosimetric accuracy with MatriXX from IBA. Compared with IMRT, the VMAT-CDR plans delivered a slightly greater V{sub 20} of the bowel, bladder, pelvis bone, and NT, but significantly decreased the dose to the high-dose region of the rectum and pelvis bone. The MUs decreased from 1105 with IMRT to 628 with VMAT-CDR. The delivery time also decreased from 9.5 to 3.2 minutes. The average gamma pass rate was 95.6% at the 3%/3 mm criteria with MatriXX pretreatment verification for 9 patients. VMAT-CDR can achieve comparable plan quality with significant shorter delivery time and smaller number of MUs compared with IMRT for patients with endometrial cancer undergoing WPRT. It can be accuratelymore » delivered and be an alternative to IMRT on the linear accelerator without VDR capability.« less

Authors:
 [1];  [1];  [2];  [3];  [1]
  1. Department of Radiation Oncology, Peking University Third Hospital, Beijing (China)
  2. Department of Biomedical Engineering, Peking University Third Hospital, Beijing (China)
  3. Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing (China)
Publication Date:
OSTI Identifier:
22262834
Resource Type:
Journal Article
Journal Name:
Medical Dosimetry
Additional Journal Information:
Journal Volume: 38; Journal Issue: 3; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0958-3947
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; COMPARATIVE EVALUATIONS; EXTERNAL BEAM RADIATION THERAPY; LINEAR ACCELERATORS; NEOPLASMS; RECTUM

Citation Formats

Yang, Ruijie, Wang, Junjie, Xu, Feng, Li, Hua, and Zhang, Xile. Feasibility study of volumetric modulated arc therapy with constant dose rate for endometrial cancer. United States: N. p., 2013. Web. doi:10.1016/J.MEDDOS.2013.04.001.
Yang, Ruijie, Wang, Junjie, Xu, Feng, Li, Hua, & Zhang, Xile. Feasibility study of volumetric modulated arc therapy with constant dose rate for endometrial cancer. United States. https://doi.org/10.1016/J.MEDDOS.2013.04.001
Yang, Ruijie, Wang, Junjie, Xu, Feng, Li, Hua, and Zhang, Xile. 2013. "Feasibility study of volumetric modulated arc therapy with constant dose rate for endometrial cancer". United States. https://doi.org/10.1016/J.MEDDOS.2013.04.001.
@article{osti_22262834,
title = {Feasibility study of volumetric modulated arc therapy with constant dose rate for endometrial cancer},
author = {Yang, Ruijie and Wang, Junjie and Xu, Feng and Li, Hua and Zhang, Xile},
abstractNote = {To investigate the feasibility, efficiency, and delivery accuracy of volumetric modulated arc therapy with constant dose rate (VMAT-CDR) for whole-pelvic radiotherapy (WPRT) of endometrial cancer. The nine-field intensity-modulated radiotherapy (IMRT), VMAT with variable dose-rate (VMAT-VDR), and VMAT-CDR plans were created for 9 patients with endometrial cancer undergoing WPRT. The dose distribution of planning target volume (PTV), organs at risk (OARs), and normal tissue (NT) were compared. The monitor units (MUs) and treatment delivery time were also evaluated. For each VMAT-CDR plan, a dry run was performed to assess the dosimetric accuracy with MatriXX from IBA. Compared with IMRT, the VMAT-CDR plans delivered a slightly greater V{sub 20} of the bowel, bladder, pelvis bone, and NT, but significantly decreased the dose to the high-dose region of the rectum and pelvis bone. The MUs decreased from 1105 with IMRT to 628 with VMAT-CDR. The delivery time also decreased from 9.5 to 3.2 minutes. The average gamma pass rate was 95.6% at the 3%/3 mm criteria with MatriXX pretreatment verification for 9 patients. VMAT-CDR can achieve comparable plan quality with significant shorter delivery time and smaller number of MUs compared with IMRT for patients with endometrial cancer undergoing WPRT. It can be accurately delivered and be an alternative to IMRT on the linear accelerator without VDR capability.},
doi = {10.1016/J.MEDDOS.2013.04.001},
url = {https://www.osti.gov/biblio/22262834}, journal = {Medical Dosimetry},
issn = {0958-3947},
number = 3,
volume = 38,
place = {United States},
year = {Tue Oct 01 00:00:00 EDT 2013},
month = {Tue Oct 01 00:00:00 EDT 2013}
}