Multifield optimization intensity-modulated proton therapy (MFO-IMPT) for prostate cancer: Robustness analysis through simulation of rotational and translational alignment errors

Amos, Richard A.; John Baptiste, Sandra; Choi, Seungtaek; Nhu Nguyen, Quyhn; Ronald Zhu, X.; Palmer, Matthew B.; Lee, Andrew K.

doi:10.1016/J.MEDDOS.2013.03.007

Title: Multifield optimization intensity-modulated proton therapy (MFO-IMPT) for prostate cancer: Robustness analysis through simulation of rotational and translational alignment errors

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Abstract

To evaluate the dosimetric consequences of rotational and translational alignment errors in patients receiving intensity-modulated proton therapy with multifield optimization (MFO-IMPT) for prostate cancer. Ten control patients with localized prostate cancer underwent treatment planning for MFO-IMPT. Rotational and translation errors were simulated along each of 3 axes: anterior-posterior (A-P), superior-inferior (S-I), and left-right. Clinical target-volume (CTV) coverage remained high with all alignment errors simulated. Rotational errors did not result in significant rectum or bladder dose perturbations. Translational errors resulted in larger dose perturbations to the bladder and rectum. Perturbations in rectum and bladder doses were minimal for rotational errors and larger for translational errors. Rectum V45 and V70 increased most with A-P misalignment, whereas bladder V45 and V70 changed most with S-I misalignment. The bladder and rectum V45 and V70 remained acceptable even with extreme alignment errors. Even with S-I and A-P translational errors of up to 5 mm, the dosimetric profile of MFO-IMPT remained favorable. MFO-IMPT for localized prostate cancer results in robust coverage of the CTV without clinically meaningful dose perturbations to normal tissue despite extreme rotational and translational alignment errors.

Authors:

Amos, Richard A. ^[1]; John Baptiste, Sandra; Choi, Seungtaek; Nhu Nguyen, Quyhn ^[2]; Ronald Zhu, X. ^[1]; Palmer, Matthew B.; Lee, Andrew K. ^[2]

Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX (United States)
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX (United States)

Publication Date:: Tue Oct 01 00:00:00 EDT 2013

OSTI Identifier:: 22262833

Resource Type:: Journal Article

Journal Name:: Medical Dosimetry

Additional Journal Information:: Journal Volume: 38; Journal Issue: 3; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0958-3947

Country of Publication:: United States

Language:: English

Subject:: 61 RADIATION PROTECTION AND DOSIMETRY; BLADDER; ERRORS; NEOPLASMS; OPTIMIZATION; PROSTATE; PROTON BEAMS; RADIATION DOSES; RECTUM; THERAPY

Citation Formats


                    Pugh, Thomas J., E-mail: tpugh@mdanderson.org, Amos, Richard A., John Baptiste, Sandra, Choi, Seungtaek, Nhu Nguyen, Quyhn, Ronald Zhu, X., Palmer, Matthew B., and Lee, Andrew K. Multifield optimization intensity-modulated proton therapy (MFO-IMPT) for prostate cancer: Robustness analysis through simulation of rotational and translational alignment errors.  United States: N. p., 2013. 
        Web.  doi:10.1016/J.MEDDOS.2013.03.007.

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                    Pugh, Thomas J., E-mail: tpugh@mdanderson.org, Amos, Richard A., John Baptiste, Sandra, Choi, Seungtaek, Nhu Nguyen, Quyhn, Ronald Zhu, X., Palmer, Matthew B., & Lee, Andrew K. Multifield optimization intensity-modulated proton therapy (MFO-IMPT) for prostate cancer: Robustness analysis through simulation of rotational and translational alignment errors.  United States.  https://doi.org/10.1016/J.MEDDOS.2013.03.007

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                    Pugh, Thomas J., E-mail: tpugh@mdanderson.org, Amos, Richard A., John Baptiste, Sandra, Choi, Seungtaek, Nhu Nguyen, Quyhn, Ronald Zhu, X., Palmer, Matthew B., and Lee, Andrew K. 2013.  
        "Multifield optimization intensity-modulated proton therapy (MFO-IMPT) for prostate cancer: Robustness analysis through simulation of rotational and translational alignment errors".  United States.  https://doi.org/10.1016/J.MEDDOS.2013.03.007.

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@article{osti_22262833,

  title        = {Multifield optimization intensity-modulated proton therapy (MFO-IMPT) for prostate cancer: Robustness analysis through simulation of rotational and translational alignment errors},

  author       = {Pugh, Thomas J., E-mail: tpugh@mdanderson.org and Amos, Richard A. and John Baptiste, Sandra and Choi, Seungtaek and Nhu Nguyen, Quyhn and Ronald Zhu, X. and Palmer, Matthew B. and Lee, Andrew K.},

  abstractNote = {To evaluate the dosimetric consequences of rotational and translational alignment errors in patients receiving intensity-modulated proton therapy with multifield optimization (MFO-IMPT) for prostate cancer. Ten control patients with localized prostate cancer underwent treatment planning for MFO-IMPT. Rotational and translation errors were simulated along each of 3 axes: anterior-posterior (A-P), superior-inferior (S-I), and left-right. Clinical target-volume (CTV) coverage remained high with all alignment errors simulated. Rotational errors did not result in significant rectum or bladder dose perturbations. Translational errors resulted in larger dose perturbations to the bladder and rectum. Perturbations in rectum and bladder doses were minimal for rotational errors and larger for translational errors. Rectum V45 and V70 increased most with A-P misalignment, whereas bladder V45 and V70 changed most with S-I misalignment. The bladder and rectum V45 and V70 remained acceptable even with extreme alignment errors. Even with S-I and A-P translational errors of up to 5 mm, the dosimetric profile of MFO-IMPT remained favorable. MFO-IMPT for localized prostate cancer results in robust coverage of the CTV without clinically meaningful dose perturbations to normal tissue despite extreme rotational and translational alignment errors.},

  doi          = {10.1016/J.MEDDOS.2013.03.007},

  url          = {https://www.osti.gov/biblio/22262833},
  journal      = {Medical Dosimetry},

  issn         = {0958-3947},

  number       = 3,

  volume       = 38,

  place        = {United States},

  year         = {Tue Oct 01 00:00:00 EDT 2013},

  month        = {Tue Oct 01 00:00:00 EDT 2013}

}

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