Comparison study of the partial-breast irradiation techniques: Dosimetric analysis of three-dimensional conformal radiation therapy, electron beam therapy, and helical tomotherapy depending on various tumor locations
Abstract
The partial-breast irradiation (PBI) technique, an alternative to whole-breast irradiation, is a beam delivery method that uses a limited range of treatment volume. The present study was designed to determine the optimal PBI treatment modalities for 8 different tumor locations. Treatment planning was performed on computed tomography (CT) data sets of 6 patients who had received lumpectomy treatments. Tumor locations were classified into 8 subsections according to breast quadrant and depth. Three-dimensional conformal radiation therapy (3D-CRT), electron beam therapy (ET), and helical tomotherapy (H-TOMO) were utilized to evaluate the dosimetric effect for each tumor location. Conformation number (CN), radical dose homogeneity index (rDHI), and dose delivered to healthy tissue were estimated. The Kruskal-Wallis, Mann-Whitney U, and Bonferroni tests were used for statistical analysis. The ET approach showed good sparing effects and acceptable target coverage for the lower inner quadrant—superficial (LIQ-S) and lower inner quadrant—deep (LIQ-D) locations. The H-TOMO method was the least effective technique as no evaluation index achieved superiority for all tumor locations except CN. The ET method is advisable for treating LIQ-S and LIQ-D tumors, as opposed to 3D-CRT or H-TOMO, because of acceptable target coverage and much lower dose applied to surrounding tissue.
- Authors:
-
- Department of Biomedical Engineering, The Catholic University of Korea, Seoul (Korea, Republic of)
- Department of Radiation Oncology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul (Korea, Republic of)
- Publication Date:
- OSTI Identifier:
- 22262831
- Resource Type:
- Journal Article
- Journal Name:
- Medical Dosimetry
- Additional Journal Information:
- Journal Volume: 38; Journal Issue: 3; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0958-3947
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 61 RADIATION PROTECTION AND DOSIMETRY; COMPUTERIZED TOMOGRAPHY; CT-GUIDED RADIOTHERAPY; ELECTRON BEAMS; NEOPLASMS; RADIATION DOSES
Citation Formats
Kim, Min-Joo, Park, So-Hyun, Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul, Son, Seok-Hyun, Cheon, Keum-Seong, Choi, Byung-Ock, Suh, Tae-Suk, and Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul. Comparison study of the partial-breast irradiation techniques: Dosimetric analysis of three-dimensional conformal radiation therapy, electron beam therapy, and helical tomotherapy depending on various tumor locations. United States: N. p., 2013.
Web. doi:10.1016/J.MEDDOS.2013.03.004.
Kim, Min-Joo, Park, So-Hyun, Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul, Son, Seok-Hyun, Cheon, Keum-Seong, Choi, Byung-Ock, Suh, Tae-Suk, & Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul. Comparison study of the partial-breast irradiation techniques: Dosimetric analysis of three-dimensional conformal radiation therapy, electron beam therapy, and helical tomotherapy depending on various tumor locations. United States. https://doi.org/10.1016/J.MEDDOS.2013.03.004
Kim, Min-Joo, Park, So-Hyun, Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul, Son, Seok-Hyun, Cheon, Keum-Seong, Choi, Byung-Ock, Suh, Tae-Suk, and Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul. 2013.
"Comparison study of the partial-breast irradiation techniques: Dosimetric analysis of three-dimensional conformal radiation therapy, electron beam therapy, and helical tomotherapy depending on various tumor locations". United States. https://doi.org/10.1016/J.MEDDOS.2013.03.004.
@article{osti_22262831,
title = {Comparison study of the partial-breast irradiation techniques: Dosimetric analysis of three-dimensional conformal radiation therapy, electron beam therapy, and helical tomotherapy depending on various tumor locations},
author = {Kim, Min-Joo and Park, So-Hyun and Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul and Son, Seok-Hyun and Cheon, Keum-Seong and Choi, Byung-Ock and Suh, Tae-Suk and Research Institute of Biomedical Engineering, The Catholic University of Korea, Seoul},
abstractNote = {The partial-breast irradiation (PBI) technique, an alternative to whole-breast irradiation, is a beam delivery method that uses a limited range of treatment volume. The present study was designed to determine the optimal PBI treatment modalities for 8 different tumor locations. Treatment planning was performed on computed tomography (CT) data sets of 6 patients who had received lumpectomy treatments. Tumor locations were classified into 8 subsections according to breast quadrant and depth. Three-dimensional conformal radiation therapy (3D-CRT), electron beam therapy (ET), and helical tomotherapy (H-TOMO) were utilized to evaluate the dosimetric effect for each tumor location. Conformation number (CN), radical dose homogeneity index (rDHI), and dose delivered to healthy tissue were estimated. The Kruskal-Wallis, Mann-Whitney U, and Bonferroni tests were used for statistical analysis. The ET approach showed good sparing effects and acceptable target coverage for the lower inner quadrant—superficial (LIQ-S) and lower inner quadrant—deep (LIQ-D) locations. The H-TOMO method was the least effective technique as no evaluation index achieved superiority for all tumor locations except CN. The ET method is advisable for treating LIQ-S and LIQ-D tumors, as opposed to 3D-CRT or H-TOMO, because of acceptable target coverage and much lower dose applied to surrounding tissue.},
doi = {10.1016/J.MEDDOS.2013.03.004},
url = {https://www.osti.gov/biblio/22262831},
journal = {Medical Dosimetry},
issn = {0958-3947},
number = 3,
volume = 38,
place = {United States},
year = {Tue Oct 01 00:00:00 EDT 2013},
month = {Tue Oct 01 00:00:00 EDT 2013}
}