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Title: Disorganization of cell division of methicillin-resistant Staphylococcus aureus by methanolic extract from Phyllanthus columnaris stem bark

Abstract

The in vitro activity of methanolic extract from Phyllanthus columnaris stem bark was studied against Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 and MRSA BM1 (clinical strain) using time-kill curves in conjunction with scanning and transmission electron microscopy. The extract showed more markedly bactericidal activity in MRSA BM1 clinical strain within less than 4 h by 6.25-12.5 mg/mL and within 6 h by 1.56 mg/mL. Scanning electron microscopy of MRSA BM1 revealed distortion of cell whilst transmission electron microscopy revealed disruption in cell wall division.

Authors:
;  [1];  [2]
  1. School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia)
  2. School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia)
Publication Date:
OSTI Identifier:
22262697
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1571; Journal Issue: 1; Conference: 2013 UKM FST postgraduate colloquium, Selangor (Malaysia), 3-4 Jul 2013; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CELL DIVISION; IN VITRO; SCANNING ELECTRON MICROSCOPY; STAPHYLOCOCCUS; TRANSMISSION ELECTRON MICROSCOPY

Citation Formats

Adnalizawati, A. Siti Noor, Nazlina, I., and Yaacob, W. A. Disorganization of cell division of methicillin-resistant Staphylococcus aureus by methanolic extract from Phyllanthus columnaris stem bark. United States: N. p., 2013. Web. doi:10.1063/1.4858658.
Adnalizawati, A. Siti Noor, Nazlina, I., & Yaacob, W. A. Disorganization of cell division of methicillin-resistant Staphylococcus aureus by methanolic extract from Phyllanthus columnaris stem bark. United States. https://doi.org/10.1063/1.4858658
Adnalizawati, A. Siti Noor, Nazlina, I., and Yaacob, W. A. 2013. "Disorganization of cell division of methicillin-resistant Staphylococcus aureus by methanolic extract from Phyllanthus columnaris stem bark". United States. https://doi.org/10.1063/1.4858658.
@article{osti_22262697,
title = {Disorganization of cell division of methicillin-resistant Staphylococcus aureus by methanolic extract from Phyllanthus columnaris stem bark},
author = {Adnalizawati, A. Siti Noor and Nazlina, I. and Yaacob, W. A.},
abstractNote = {The in vitro activity of methanolic extract from Phyllanthus columnaris stem bark was studied against Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 and MRSA BM1 (clinical strain) using time-kill curves in conjunction with scanning and transmission electron microscopy. The extract showed more markedly bactericidal activity in MRSA BM1 clinical strain within less than 4 h by 6.25-12.5 mg/mL and within 6 h by 1.56 mg/mL. Scanning electron microscopy of MRSA BM1 revealed distortion of cell whilst transmission electron microscopy revealed disruption in cell wall division.},
doi = {10.1063/1.4858658},
url = {https://www.osti.gov/biblio/22262697}, journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1571,
place = {United States},
year = {Wed Nov 27 00:00:00 EST 2013},
month = {Wed Nov 27 00:00:00 EST 2013}
}