Disorganization of cell division of methicillin-resistant Staphylococcus aureus by methanolic extract from Phyllanthus columnaris stem bark
Abstract
The in vitro activity of methanolic extract from Phyllanthus columnaris stem bark was studied against Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 and MRSA BM1 (clinical strain) using time-kill curves in conjunction with scanning and transmission electron microscopy. The extract showed more markedly bactericidal activity in MRSA BM1 clinical strain within less than 4 h by 6.25-12.5 mg/mL and within 6 h by 1.56 mg/mL. Scanning electron microscopy of MRSA BM1 revealed distortion of cell whilst transmission electron microscopy revealed disruption in cell wall division.
- Authors:
-
- School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia)
- School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor (Malaysia)
- Publication Date:
- OSTI Identifier:
- 22262697
- Resource Type:
- Journal Article
- Journal Name:
- AIP Conference Proceedings
- Additional Journal Information:
- Journal Volume: 1571; Journal Issue: 1; Conference: 2013 UKM FST postgraduate colloquium, Selangor (Malaysia), 3-4 Jul 2013; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; CELL DIVISION; IN VITRO; SCANNING ELECTRON MICROSCOPY; STAPHYLOCOCCUS; TRANSMISSION ELECTRON MICROSCOPY
Citation Formats
Adnalizawati, A. Siti Noor, Nazlina, I., and Yaacob, W. A. Disorganization of cell division of methicillin-resistant Staphylococcus aureus by methanolic extract from Phyllanthus columnaris stem bark. United States: N. p., 2013.
Web. doi:10.1063/1.4858658.
Adnalizawati, A. Siti Noor, Nazlina, I., & Yaacob, W. A. Disorganization of cell division of methicillin-resistant Staphylococcus aureus by methanolic extract from Phyllanthus columnaris stem bark. United States. https://doi.org/10.1063/1.4858658
Adnalizawati, A. Siti Noor, Nazlina, I., and Yaacob, W. A. 2013.
"Disorganization of cell division of methicillin-resistant Staphylococcus aureus by methanolic extract from Phyllanthus columnaris stem bark". United States. https://doi.org/10.1063/1.4858658.
@article{osti_22262697,
title = {Disorganization of cell division of methicillin-resistant Staphylococcus aureus by methanolic extract from Phyllanthus columnaris stem bark},
author = {Adnalizawati, A. Siti Noor and Nazlina, I. and Yaacob, W. A.},
abstractNote = {The in vitro activity of methanolic extract from Phyllanthus columnaris stem bark was studied against Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 and MRSA BM1 (clinical strain) using time-kill curves in conjunction with scanning and transmission electron microscopy. The extract showed more markedly bactericidal activity in MRSA BM1 clinical strain within less than 4 h by 6.25-12.5 mg/mL and within 6 h by 1.56 mg/mL. Scanning electron microscopy of MRSA BM1 revealed distortion of cell whilst transmission electron microscopy revealed disruption in cell wall division.},
doi = {10.1063/1.4858658},
url = {https://www.osti.gov/biblio/22262697},
journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1571,
place = {United States},
year = {Wed Nov 27 00:00:00 EST 2013},
month = {Wed Nov 27 00:00:00 EST 2013}
}
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