Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction
Abstract
Purpose: To assess the performance of two approaches to the system response matrix (SRM) calculation in pinhole single photon emission computed tomography (SPECT) reconstruction. Methods: Evaluation was performed using experimental data from a low magnification pinhole SPECT system that consisted of a rotating flat detector with a monolithic scintillator crystal. The SRM was computed following two approaches, which were based on Monte Carlo simulations (MC-SRM) and analytical techniques in combination with an experimental characterization (AE-SRM). The spatial response of the system, obtained by using the two approaches, was compared with experimental data. The effect of the MC-SRM and AE-SRM approaches on the reconstructed image was assessed in terms of image contrast, signal-to-noise ratio, image quality, and spatial resolution. To this end, acquisitions were carried out using a hot cylinder phantom (consisting of five fillable rods with diameters of 5, 4, 3, 2, and 1 mm and a uniform cylindrical chamber) and a custom-made Derenzo phantom, with center-to-center distances between adjacent rods of 1.5, 2.0, and 3.0 mm. Results: Good agreement was found for the spatial response of the system between measured data and results derived from MC-SRM and AE-SRM. Only minor differences for point sources at distances smaller than the radius ofmore »
- Authors:
-
- Fundación Ramón Domínguez, Medicina Nuclear, CHUS, Spain and Grupo de Imaxe Molecular, IDIS, Santiago de Compostela 15706 (Spain)
- Unitat de Biofísica, Facultat de Medicina, Universitat de Barcelona, Spain and Servei de Física Médica i Protecció Radiológica, Institut Catalá d'Oncologia, Barcelona 08036 (Spain)
- Fundación Ramón Domínguez, Medicina Nuclear, CHUS, Santiago de Compostela 15706 (Spain)
- Servei de Medicina Nuclear, Hospital Clínic, Barcelona (Spain)
- Unitat de Biofísica, Facultat de Medicina, Casanova 143 (Spain)
- Servicio Medicina Nuclear, CHUS (Spain)
- Spain
- Publication Date:
- OSTI Identifier:
- 22250941
- Resource Type:
- Journal Article
- Journal Name:
- Medical Physics
- Additional Journal Information:
- Journal Volume: 41; Journal Issue: 3; Other Information: (c) 2014 Author(s); Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; CALIBRATION STANDARDS; COMPUTERIZED SIMULATION; EXPERIMENTAL DATA; IMAGES; INCIDENCE ANGLE; MONTE CARLO METHOD; PHANTOMS; POINT SOURCES; SIGNAL-TO-NOISE RATIO; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SPATIAL RESOLUTION
Citation Formats
Aguiar, Pablo, Pino, Francisco, Silva-Rodríguez, Jesús, Pavía, Javier, Institut d'Investigacions Biomèdiques August Pí i Sunyer, CIBER en Bioingeniería, Biomateriales y Nanomedicina, Ros, Doménec, Institut d'Investigacions Biomèdiques August Pí i Sunyer, CIBER en Bioingeniería, Biomateriales y Nanomedicina, Ruibal, Álvaro, Grupo de Imaxe Molecular, Facultade de Medicina, Fundación Tejerina, Madrid, and others, and. Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction. United States: N. p., 2014.
Web. doi:10.1118/1.4866380.
Aguiar, Pablo, Pino, Francisco, Silva-Rodríguez, Jesús, Pavía, Javier, Institut d'Investigacions Biomèdiques August Pí i Sunyer, CIBER en Bioingeniería, Biomateriales y Nanomedicina, Ros, Doménec, Institut d'Investigacions Biomèdiques August Pí i Sunyer, CIBER en Bioingeniería, Biomateriales y Nanomedicina, Ruibal, Álvaro, Grupo de Imaxe Molecular, Facultade de Medicina, Fundación Tejerina, Madrid, & others, and. Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction. United States. https://doi.org/10.1118/1.4866380
Aguiar, Pablo, Pino, Francisco, Silva-Rodríguez, Jesús, Pavía, Javier, Institut d'Investigacions Biomèdiques August Pí i Sunyer, CIBER en Bioingeniería, Biomateriales y Nanomedicina, Ros, Doménec, Institut d'Investigacions Biomèdiques August Pí i Sunyer, CIBER en Bioingeniería, Biomateriales y Nanomedicina, Ruibal, Álvaro, Grupo de Imaxe Molecular, Facultade de Medicina, Fundación Tejerina, Madrid, and others, and. 2014.
"Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction". United States. https://doi.org/10.1118/1.4866380.
@article{osti_22250941,
title = {Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction},
author = {Aguiar, Pablo and Pino, Francisco and Silva-Rodríguez, Jesús and Pavía, Javier and Institut d'Investigacions Biomèdiques August Pí i Sunyer and CIBER en Bioingeniería, Biomateriales y Nanomedicina and Ros, Doménec and Institut d'Investigacions Biomèdiques August Pí i Sunyer and CIBER en Bioingeniería, Biomateriales y Nanomedicina and Ruibal, Álvaro and Grupo de Imaxe Molecular, Facultade de Medicina and Fundación Tejerina, Madrid and others, and},
abstractNote = {Purpose: To assess the performance of two approaches to the system response matrix (SRM) calculation in pinhole single photon emission computed tomography (SPECT) reconstruction. Methods: Evaluation was performed using experimental data from a low magnification pinhole SPECT system that consisted of a rotating flat detector with a monolithic scintillator crystal. The SRM was computed following two approaches, which were based on Monte Carlo simulations (MC-SRM) and analytical techniques in combination with an experimental characterization (AE-SRM). The spatial response of the system, obtained by using the two approaches, was compared with experimental data. The effect of the MC-SRM and AE-SRM approaches on the reconstructed image was assessed in terms of image contrast, signal-to-noise ratio, image quality, and spatial resolution. To this end, acquisitions were carried out using a hot cylinder phantom (consisting of five fillable rods with diameters of 5, 4, 3, 2, and 1 mm and a uniform cylindrical chamber) and a custom-made Derenzo phantom, with center-to-center distances between adjacent rods of 1.5, 2.0, and 3.0 mm. Results: Good agreement was found for the spatial response of the system between measured data and results derived from MC-SRM and AE-SRM. Only minor differences for point sources at distances smaller than the radius of rotation and large incidence angles were found. Assessment of the effect on the reconstructed image showed a similar contrast for both approaches, with values higher than 0.9 for rod diameters greater than 1 mm and higher than 0.8 for rod diameter of 1 mm. The comparison in terms of image quality showed that all rods in the different sections of a custom-made Derenzo phantom could be distinguished. The spatial resolution (FWHM) was 0.7 mm at iteration 100 using both approaches. The SNR was lower for reconstructed images using MC-SRM than for those reconstructed using AE-SRM, indicating that AE-SRM deals better with the projection noise than MC-SRM. Conclusions: The authors' findings show that both approaches provide good solutions to the problem of calculating the SRM in pinhole SPECT reconstruction. The AE-SRM was faster to create and handle the projection noise better than MC-SRM. Nevertheless, the AE-SRM required a tedious experimental characterization of the intrinsic detector response. Creation of the MC-SRM required longer computation time and handled the projection noise worse than the AE-SRM. Nevertheless, the MC-SRM inherently incorporates extensive modeling of the system and therefore experimental characterization was not required.},
doi = {10.1118/1.4866380},
url = {https://www.osti.gov/biblio/22250941},
journal = {Medical Physics},
issn = {0094-2405},
number = 3,
volume = 41,
place = {United States},
year = {Sat Mar 15 00:00:00 EDT 2014},
month = {Sat Mar 15 00:00:00 EDT 2014}
}