Total Gross Tumor Volume Is an Independent Prognostic Factor in Patients Treated With Selective Nodal Irradiation for Stage I to III Small Cell Lung Cancer

Reymen, Bart; Van Loon, Judith; Baardwijk, Angela van; Wanders, Rinus; Borger, Jacques; Dingemans, Anne-Marie C.; Bootsma, Gerben; Pitz, Cordula; Lunde, Ragnar; Geraedts, Wiel; Lambin, Philippe; De Ruysscher, Dirk

doi:10.1016/J.IJROBP.2012.10.003

Title: Total Gross Tumor Volume Is an Independent Prognostic Factor in Patients Treated With Selective Nodal Irradiation for Stage I to III Small Cell Lung Cancer

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Abstract

Purpose: In non-small cell lung cancer, gross tumor volume (GTV) influences survival more than other risk factors. This could also apply to small cell lung cancer. Methods and Materials: Analysis of our prospective database with stage I to III SCLC patients referred for concurrent chemo radiation therapy. Standard treatment was 45 Gy in 1.5-Gy fractions twice daily concurrently with carboplatin-etoposide, followed by prophylactic cranial irradiation (PCI) in case of non-progression. Only fluorodeoxyglucose (FDG)-positron emission tomography (PET)-positive or pathologically proven nodal sites were included in the target volume. Total GTV consisted of post chemotherapy tumor volume and pre chemotherapy nodal volume. Survival was calculated from diagnosis (Kaplan-Meier ). Results: A total of 119 patients were included between May 2004 and June 2009. Median total GTV was 93 ± 152 cc (7.5-895 cc). Isolated elective nodal failure occurred in 2 patients (1.7%). Median follow-up was 38 months, median overall survival 20 months (95% confidence interval = 17.8-22.1 months), and 2-year survival 38.4%. In multivariate analysis, only total GTV (P=.026) and performance status (P=.016) significantly influenced survival. Conclusions: In this series of stage I to III small cell lung cancer patients treated with FDG-PET-based selective nodal irradiation total GTV is an independent riskmore » factor for survival.« less

Authors:

Reymen, Bart ^[1]; Van Loon, Judith; Baardwijk, Angela van; Wanders, Rinus; Borger, Jacques ^[1]; Dingemans, Anne-Marie C. ^[2]; Bootsma, Gerben ^[3]; Pitz, Cordula ^[4]; Lunde, Ragnar ^[5]; Geraedts, Wiel ^[6]; Lambin, Philippe ^[1]; De Ruysscher, Dirk ^[1]

Department of Radiation Oncology (MAASTRO clinic), GROW – School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht (Netherlands)
Department of Pulmonology, GROW – School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht (Netherlands)
Department of Pulmonology, Atrium Medical Centre, Heerlen (Netherlands)
Department of Pulmonology, Laurentius Hospital, Roermond (Netherlands)
Department of Pulmonology, St Jansgasthuis, Weert (Netherlands)
Department of Pulmonology, Orbis Medical Centre, Sittard (Netherlands)

Publication Date:: Mon Apr 01 00:00:00 EDT 2013

OSTI Identifier:: 22224424

Resource Type:: Journal Article

Journal Name:: International Journal of Radiation Oncology, Biology and Physics

Additional Journal Information:: Journal Volume: 85; Journal Issue: 5; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; DIAGNOSIS; FAILURES; FLUORODEOXYGLUCOSE; HEALTH HAZARDS; IRRADIATION; LUNGS; NEOPLASMS; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; RADIOTHERAPY

Citation Formats


                    Reymen, Bart, Van Loon, Judith, Baardwijk, Angela van, Wanders, Rinus, Borger, Jacques, Dingemans, Anne-Marie C., Bootsma, Gerben, Pitz, Cordula, Lunde, Ragnar, Geraedts, Wiel, Lambin, Philippe, De Ruysscher, Dirk, and University Hospital Leuven/ KU Leuven, Leuven. Total Gross Tumor Volume Is an Independent Prognostic Factor in Patients Treated With Selective Nodal Irradiation for Stage I to III Small Cell Lung Cancer.  United States: N. p., 2013. 
        Web.  doi:10.1016/J.IJROBP.2012.10.003.

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                    Reymen, Bart, Van Loon, Judith, Baardwijk, Angela van, Wanders, Rinus, Borger, Jacques, Dingemans, Anne-Marie C., Bootsma, Gerben, Pitz, Cordula, Lunde, Ragnar, Geraedts, Wiel, Lambin, Philippe, De Ruysscher, Dirk, & University Hospital Leuven/ KU Leuven, Leuven. Total Gross Tumor Volume Is an Independent Prognostic Factor in Patients Treated With Selective Nodal Irradiation for Stage I to III Small Cell Lung Cancer.  United States.  https://doi.org/10.1016/J.IJROBP.2012.10.003

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                    Reymen, Bart, Van Loon, Judith, Baardwijk, Angela van, Wanders, Rinus, Borger, Jacques, Dingemans, Anne-Marie C., Bootsma, Gerben, Pitz, Cordula, Lunde, Ragnar, Geraedts, Wiel, Lambin, Philippe, De Ruysscher, Dirk, and University Hospital Leuven/ KU Leuven, Leuven. 2013.  
        "Total Gross Tumor Volume Is an Independent Prognostic Factor in Patients Treated With Selective Nodal Irradiation for Stage I to III Small Cell Lung Cancer".  United States.  https://doi.org/10.1016/J.IJROBP.2012.10.003.

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@article{osti_22224424,

  title        = {Total Gross Tumor Volume Is an Independent Prognostic Factor in Patients Treated With Selective Nodal Irradiation for Stage I to III Small Cell Lung Cancer},

  author       = {Reymen, Bart and Van Loon, Judith and Baardwijk, Angela van and Wanders, Rinus and Borger, Jacques and Dingemans, Anne-Marie C. and Bootsma, Gerben and Pitz, Cordula and Lunde, Ragnar and Geraedts, Wiel and Lambin, Philippe and De Ruysscher, Dirk and University Hospital Leuven/ KU Leuven, Leuven},

  abstractNote = {Purpose: In non-small cell lung cancer, gross tumor volume (GTV) influences survival more than other risk factors. This could also apply to small cell lung cancer. Methods and Materials: Analysis of our prospective database with stage I to III SCLC patients referred for concurrent chemo radiation therapy. Standard treatment was 45 Gy in 1.5-Gy fractions twice daily concurrently with carboplatin-etoposide, followed by prophylactic cranial irradiation (PCI) in case of non-progression. Only fluorodeoxyglucose (FDG)-positron emission tomography (PET)-positive or pathologically proven nodal sites were included in the target volume. Total GTV consisted of post chemotherapy tumor volume and pre chemotherapy nodal volume. Survival was calculated from diagnosis (Kaplan-Meier ). Results: A total of 119 patients were included between May 2004 and June 2009. Median total GTV was 93 ± 152 cc (7.5-895 cc). Isolated elective nodal failure occurred in 2 patients (1.7%). Median follow-up was 38 months, median overall survival 20 months (95% confidence interval = 17.8-22.1 months), and 2-year survival 38.4%. In multivariate analysis, only total GTV (P=.026) and performance status (P=.016) significantly influenced survival. Conclusions: In this series of stage I to III small cell lung cancer patients treated with FDG-PET-based selective nodal irradiation total GTV is an independent risk factor for survival.},

  doi          = {10.1016/J.IJROBP.2012.10.003},

  url          = {https://www.osti.gov/biblio/22224424},
  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  issn         = {0360-3016},

  number       = 5,

  volume       = 85,

  place        = {United States},

  year         = {Mon Apr 01 00:00:00 EDT 2013},

  month        = {Mon Apr 01 00:00:00 EDT 2013}

}

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