Photoactivatable carbon nanodots for cancer therapy

Journal Article · Mon Aug 05 00:00:00 EDT 2013 · Applied Physics Letters

DOI:https://doi.org/10.1063/1.4817787· OSTI ID:22218218

Juzenas, Petras; Kleinauskas, Andrius ^[1]; George Luo, Pengju; Sun, Ya-Ping ^[2]

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1. Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello 0310 Oslo (Norway)
2. Department of Chemistry and Laboratory for Emerging Materials and Technology, Clemson University, Clemson, South Carolina 29634-0973 (United States)

In this study, we describe a photocatalytic system based on spherical fluorescent carbon-core nanoparticles (nanodots) that can be activated with ultraviolet radiation. The carbon nanodots with a poly(propionylethylenimine-co-ethylenimine) coating were investigated in human prostate adenocarcinoma (Du145 and PC3) cell cultures in vitro. The cells become more sensitive to ultraviolet radiation when preincubated with the nanodots. The inverse slope of the cell survival curves is about 20–30% lower for the carbon nanodots and radiation compared to that for the radiation alone. Such photoactivatable carbon nanodots can be suggested for use in photocatalytic and photodynamic applications.

• OSTI ID: 22218218
• Journal Information: Applied Physics Letters, Vol. 103, Issue 6; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0003-6951
• Country of Publication: United States
• Language: English

Related Subjects

77 NANOSCIENCE AND NANOTECHNOLOGY
60 APPLIED LIFE SCIENCES
CARBON
CARCINOMAS
CELL CULTURES
COMPARATIVE EVALUATIONS
FILMS
FLUORESCENCE
HUMAN POPULATIONS
PHOTOCATALYSIS
POLYMERS
PROSTATE
QUANTUM DOTS
SURVIVAL CURVES
THERAPY
ULTRAVIOLET RADIATION