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Title: Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress

Abstract

Nanotechnologies are emerging as highly promising technologies in many sectors in the society. However, the increasing use of engineered nanomaterials also raises concerns about inadvertent exposure to these materials and the potential for adverse effects on human health and the environment. Despite several years of intensive investigations, a common paradigm for the understanding of nanoparticle-induced toxicity remains to be firmly established. Here, the so-called oxidative stress paradigm is scrutinized. Does oxidative stress represent a secondary event resulting inevitably from disruption of biochemical processes and the demise of the cell, or a specific, non-random event that plays a role in the induction of cellular damage e.g. apoptosis? The answer to this question will have important ramifications for the development of strategies for mitigation of adverse effects of nanoparticles. Recent examples of global lipidomics studies of nanoparticle-induced tissue damage are discussed along with proteomics and transcriptomics approaches to achieve a comprehensive understanding of the complex and interrelated molecular changes in cells and tissues exposed to nanoparticles. We also discuss instances of non-oxidative stress-mediated cellular damage resulting from direct physical interference of nanomaterials with cellular structures. -- Highlights: ► CNT induced non-random oxidative stress associated with apoptosis. ► Non-oxidative mechanisms for cellular toxicitymore » of carbon nanotubes. ► Biodegradation of CNT by cells of innate immune system. ► “Omics”-based biomarkers of CNT exposures.« less

Authors:
 [1];  [2];  [3]
  1. Department of Biopathology, University of Rome “Tor Vergata”, Rome (Italy)
  2. Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm (Sweden)
  3. Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA (United States)
Publication Date:
OSTI Identifier:
22215321
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 261; Journal Issue: 2; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; APOPTOSIS; BIODEGRADATION; BIOLOGICAL MARKERS; BIOLOGICAL STRESS; CARBON NANOTUBES; DAMAGE; OXIDATION; PUBLIC HEALTH; TOXICITY

Citation Formats

Shvedova, Anna A., E-mail: ats1@cdc.gov, Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV, University of Rome “Tor Vergata”, Rome, Pietroiusti, Antonio, Fadeel, Bengt, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, and Kagan, Valerian E. Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress. United States: N. p., 2012. Web. doi:10.1016/J.TAAP.2012.03.023.
Shvedova, Anna A., E-mail: ats1@cdc.gov, Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV, University of Rome “Tor Vergata”, Rome, Pietroiusti, Antonio, Fadeel, Bengt, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, & Kagan, Valerian E. Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress. United States. https://doi.org/10.1016/J.TAAP.2012.03.023
Shvedova, Anna A., E-mail: ats1@cdc.gov, Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV, University of Rome “Tor Vergata”, Rome, Pietroiusti, Antonio, Fadeel, Bengt, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, and Kagan, Valerian E. 2012. "Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress". United States. https://doi.org/10.1016/J.TAAP.2012.03.023.
@article{osti_22215321,
title = {Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress},
author = {Shvedova, Anna A., E-mail: ats1@cdc.gov and Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV, University of Rome “Tor Vergata”, Rome and Pietroiusti, Antonio and Fadeel, Bengt and Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA and Kagan, Valerian E.},
abstractNote = {Nanotechnologies are emerging as highly promising technologies in many sectors in the society. However, the increasing use of engineered nanomaterials also raises concerns about inadvertent exposure to these materials and the potential for adverse effects on human health and the environment. Despite several years of intensive investigations, a common paradigm for the understanding of nanoparticle-induced toxicity remains to be firmly established. Here, the so-called oxidative stress paradigm is scrutinized. Does oxidative stress represent a secondary event resulting inevitably from disruption of biochemical processes and the demise of the cell, or a specific, non-random event that plays a role in the induction of cellular damage e.g. apoptosis? The answer to this question will have important ramifications for the development of strategies for mitigation of adverse effects of nanoparticles. Recent examples of global lipidomics studies of nanoparticle-induced tissue damage are discussed along with proteomics and transcriptomics approaches to achieve a comprehensive understanding of the complex and interrelated molecular changes in cells and tissues exposed to nanoparticles. We also discuss instances of non-oxidative stress-mediated cellular damage resulting from direct physical interference of nanomaterials with cellular structures. -- Highlights: ► CNT induced non-random oxidative stress associated with apoptosis. ► Non-oxidative mechanisms for cellular toxicity of carbon nanotubes. ► Biodegradation of CNT by cells of innate immune system. ► “Omics”-based biomarkers of CNT exposures.},
doi = {10.1016/J.TAAP.2012.03.023},
url = {https://www.osti.gov/biblio/22215321}, journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 2,
volume = 261,
place = {United States},
year = {Fri Jun 01 00:00:00 EDT 2012},
month = {Fri Jun 01 00:00:00 EDT 2012}
}