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Title: RIP2: A novel player in the regulation of keratinocyte proliferation and cutaneous wound repair?

Abstract

We could recently demonstrate an important role of receptor interacting protein 4 (RIP4) in the regulation of keratinocyte differentiation. Now, we analyzed a potential role of the RIP4 homolog RIP2 in keratinocytes. Specifically, we demonstrate here that rip2 expression is induced by scratch-wounding and after the induction of differentiation in these cells. Furthermore, serum growth factors and cytokines can induce rip2, with TNF-{alpha}-dependent induction being dependent on p38 MAPK. In addition, we demonstrate that scratch-induced upregulation of rip2 expression is completely blocked by the steroid dexamethasone. Since we also show that RIP2 is an important player in the regulation of keratinocyte proliferation, these data suggest that inhibition of rip2 upregulation after wounding might contribute to the reduced and delayed wound re-epithelialization phenotype seen in glucocorticoid-treated patients.

Authors:
;  [1];  [1]
  1. Charite-University Medicine Berlin, Institute of Physiology, Arnimallee 22, D-14195 Berlin (Germany)
Publication Date:
OSTI Identifier:
22209868
Resource Type:
Journal Article
Journal Name:
Experimental Cell Research
Additional Journal Information:
Journal Volume: 316; Journal Issue: 5; Other Information: Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0014-4827
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; BIOLOGICAL REPAIR; CELL PROLIFERATION; DEXAMETHASONE; GENE REGULATION; INHIBITION; LYMPHOKINES; PHENOTYPE; RECEPTORS; WOUNDS

Citation Formats

Adams, Stephanie, Valchanova, Ralitsa S., and Munz, Barbara. RIP2: A novel player in the regulation of keratinocyte proliferation and cutaneous wound repair?. United States: N. p., 2010. Web. doi:10.1016/J.YEXCR.2009.12.001.
Adams, Stephanie, Valchanova, Ralitsa S., & Munz, Barbara. RIP2: A novel player in the regulation of keratinocyte proliferation and cutaneous wound repair?. United States. https://doi.org/10.1016/J.YEXCR.2009.12.001
Adams, Stephanie, Valchanova, Ralitsa S., and Munz, Barbara. 2010. "RIP2: A novel player in the regulation of keratinocyte proliferation and cutaneous wound repair?". United States. https://doi.org/10.1016/J.YEXCR.2009.12.001.
@article{osti_22209868,
title = {RIP2: A novel player in the regulation of keratinocyte proliferation and cutaneous wound repair?},
author = {Adams, Stephanie and Valchanova, Ralitsa S. and Munz, Barbara},
abstractNote = {We could recently demonstrate an important role of receptor interacting protein 4 (RIP4) in the regulation of keratinocyte differentiation. Now, we analyzed a potential role of the RIP4 homolog RIP2 in keratinocytes. Specifically, we demonstrate here that rip2 expression is induced by scratch-wounding and after the induction of differentiation in these cells. Furthermore, serum growth factors and cytokines can induce rip2, with TNF-{alpha}-dependent induction being dependent on p38 MAPK. In addition, we demonstrate that scratch-induced upregulation of rip2 expression is completely blocked by the steroid dexamethasone. Since we also show that RIP2 is an important player in the regulation of keratinocyte proliferation, these data suggest that inhibition of rip2 upregulation after wounding might contribute to the reduced and delayed wound re-epithelialization phenotype seen in glucocorticoid-treated patients.},
doi = {10.1016/J.YEXCR.2009.12.001},
url = {https://www.osti.gov/biblio/22209868}, journal = {Experimental Cell Research},
issn = {0014-4827},
number = 5,
volume = 316,
place = {United States},
year = {Wed Mar 10 00:00:00 EST 2010},
month = {Wed Mar 10 00:00:00 EST 2010}
}