FES kinase participates in KIT-ligand induced chemotaxis

Journal Article · Fri Feb 26 00:00:00 EST 2010 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2010.01.116· OSTI ID:22202394

Voisset, Edwige ^[1]; Lopez, Sophie ^[1]; Chaix, Amandine ^[1]; Vita, Marina ^[1]; George, Coralie ^[1]; Dubreuil, Patrice ^[1]

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1. INSERM U891, Centre de Recherche en Cancerologie de Marseille (CRCM) (France)

FES is a cytoplasmic tyrosine kinase activated by several membrane receptors, originally identified as a viral oncogene product. We have recently identified FES as a crucial effector of oncogenic KIT mutant receptor. However, FES implication in wild-type KIT receptor function was not addressed. We report here that FES interacts with KIT and is phosphorylated following activation by its ligand SCF. Unlike in the context of oncogenic KIT mutant, FES is not involved in wild-type KIT proliferation signal, or in cell adhesion. Instead, FES is required for SCF-induced chemotaxis. In conclusion, FES kinase is a mediator of wild-type KIT signalling implicated in cell migration.

• OSTI ID: 22202394
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 393, Issue 1; Other Information: Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CATTLE
CELL PROLIFERATION
LIGANDS
MUTANTS
ONCOGENES
RECEPTORS
SALTS
STEM CELLS
TYROSINE