Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4{sup +}T cells

Journal Article · Fri Aug 21 00:00:00 EDT 2009 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2009.06.027· OSTI ID:22199769

Ohnuma, Kei ^[1]; Uchiyama, Masahiko ^[1]; Hatano, Ryo; Takasawa, Wataru; Endo, Yuko ^[1]; Dang, Nam H. ^[2]; Morimoto, Chikao ^[1]

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1. Department of Rheumatology and Allergy, Research Hospital, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639 (Japan)
2. Department of Hematologic Malignancies, Nevada Cancer Institute, Las Vegas, NV 89135 (United States)

CD26 binds to caveolin-1 in antigen-presenting cells (APC), and that ligation of CD26 by caveolin-1 induces T cell proliferation in a TCR/CD3-dependent manner. We report herein the effects of CD26-caveolin-1 costimulatory blockade by fusion protein caveolin-1-Ig (Cav-Ig). Soluble Cav-Ig inhibits T cell proliferation and cytokine production in response to recall antigen, or allogeneic APC. Our data hence suggest that blocking of CD26-associated signaling by soluble Cav-Ig may be an effective approach as immunosuppressive therapy.

• OSTI ID: 22199769
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 386, Issue 2; Other Information: Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANTIGENS
CELL PROLIFERATION
PROTEINS
SIGNALS
THERAPY