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Title: MR-Guided High-Intensity Focused Ultrasound Ablation of Breast Cancer with a Dedicated Breast Platform

Abstract

Optimizing the treatment of breast cancer remains a major topic of interest. In current clinical practice, breast-conserving therapy is the standard of care for patients with localized breast cancer. Technological developments have fueled interest in less invasive breast cancer treatment. Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a completely noninvasive ablation technique. Focused beams of ultrasound are used for ablation of the target lesion without disrupting the skin and subcutaneous tissues in the beam path. MRI is an excellent imaging method for tumor targeting, treatment monitoring, and evaluation of treatment results. The combination of HIFU and MR imaging offers an opportunity for image-guided ablation of breast cancer. Previous studies of MR-HIFU in breast cancer patients reported a limited efficacy, which hampered the clinical translation of this technique. These prior studies were performed without an MR-HIFU system specifically developed for breast cancer treatment. In this article, a novel and dedicated MR-HIFU breast platform is presented. This system has been designed for safe and effective MR-HIFU ablation of breast cancer. Furthermore, both clinical and technical challenges are discussed, which have to be solved before MR-HIFU ablation of breast cancer can be implemented in routine clinical practice.

Authors:
 [1];
  1. University Medical Center Utrecht, Image Sciences Institute (Netherlands)
Publication Date:
OSTI Identifier:
22156359
Resource Type:
Journal Article
Journal Name:
Cardiovascular and Interventional Radiology
Additional Journal Information:
Journal Volume: 36; Journal Issue: 2; Other Information: Copyright (c) 2013 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0174-1551
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ABLATION; EVALUATION; IMAGES; MAGNETIC RESONANCE; MONITORING; NMR IMAGING; PATIENTS; SKIN; THERAPY

Citation Formats

Merckel, Laura G., E-mail: L.G.Merckel-2@umcutrecht.nl, Bartels, Lambertus W., E-mail: W.Bartels@umcutrecht.nl, Koehler, Max O., E-mail: max.kohler@philips.com, Bongard, H. J. G. Desiree van den, E-mail: D.vandenBongard@umcutrecht.nl, Deckers, Roel, Mali, Willem P. Th. M., E-mail: W.Mali@umcutrecht.nl, Binkert, Christoph A., E-mail: Christoph.Binkert@ksw.ch, Moonen, Chrit T., E-mail: C.Moonen@umcutrecht.nl, Gilhuijs, Kenneth G. A.,, and Bosch, Maurice A. A. J. van den, E-mail: mbosch@umcutrecht.nl. MR-Guided High-Intensity Focused Ultrasound Ablation of Breast Cancer with a Dedicated Breast Platform. United States: N. p., 2013. Web. doi:10.1007/S00270-012-0526-6.
Merckel, Laura G., E-mail: L.G.Merckel-2@umcutrecht.nl, Bartels, Lambertus W., E-mail: W.Bartels@umcutrecht.nl, Koehler, Max O., E-mail: max.kohler@philips.com, Bongard, H. J. G. Desiree van den, E-mail: D.vandenBongard@umcutrecht.nl, Deckers, Roel, Mali, Willem P. Th. M., E-mail: W.Mali@umcutrecht.nl, Binkert, Christoph A., E-mail: Christoph.Binkert@ksw.ch, Moonen, Chrit T., E-mail: C.Moonen@umcutrecht.nl, Gilhuijs, Kenneth G. A.,, & Bosch, Maurice A. A. J. van den, E-mail: mbosch@umcutrecht.nl. MR-Guided High-Intensity Focused Ultrasound Ablation of Breast Cancer with a Dedicated Breast Platform. United States. https://doi.org/10.1007/S00270-012-0526-6
Merckel, Laura G., E-mail: L.G.Merckel-2@umcutrecht.nl, Bartels, Lambertus W., E-mail: W.Bartels@umcutrecht.nl, Koehler, Max O., E-mail: max.kohler@philips.com, Bongard, H. J. G. Desiree van den, E-mail: D.vandenBongard@umcutrecht.nl, Deckers, Roel, Mali, Willem P. Th. M., E-mail: W.Mali@umcutrecht.nl, Binkert, Christoph A., E-mail: Christoph.Binkert@ksw.ch, Moonen, Chrit T., E-mail: C.Moonen@umcutrecht.nl, Gilhuijs, Kenneth G. A.,, and Bosch, Maurice A. A. J. van den, E-mail: mbosch@umcutrecht.nl. 2013. "MR-Guided High-Intensity Focused Ultrasound Ablation of Breast Cancer with a Dedicated Breast Platform". United States. https://doi.org/10.1007/S00270-012-0526-6.
@article{osti_22156359,
title = {MR-Guided High-Intensity Focused Ultrasound Ablation of Breast Cancer with a Dedicated Breast Platform},
author = {Merckel, Laura G., E-mail: L.G.Merckel-2@umcutrecht.nl and Bartels, Lambertus W., E-mail: W.Bartels@umcutrecht.nl and Koehler, Max O., E-mail: max.kohler@philips.com and Bongard, H. J. G. Desiree van den, E-mail: D.vandenBongard@umcutrecht.nl and Deckers, Roel and Mali, Willem P. Th. M., E-mail: W.Mali@umcutrecht.nl and Binkert, Christoph A., E-mail: Christoph.Binkert@ksw.ch and Moonen, Chrit T., E-mail: C.Moonen@umcutrecht.nl and Gilhuijs, Kenneth G. A., and Bosch, Maurice A. A. J. van den, E-mail: mbosch@umcutrecht.nl},
abstractNote = {Optimizing the treatment of breast cancer remains a major topic of interest. In current clinical practice, breast-conserving therapy is the standard of care for patients with localized breast cancer. Technological developments have fueled interest in less invasive breast cancer treatment. Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a completely noninvasive ablation technique. Focused beams of ultrasound are used for ablation of the target lesion without disrupting the skin and subcutaneous tissues in the beam path. MRI is an excellent imaging method for tumor targeting, treatment monitoring, and evaluation of treatment results. The combination of HIFU and MR imaging offers an opportunity for image-guided ablation of breast cancer. Previous studies of MR-HIFU in breast cancer patients reported a limited efficacy, which hampered the clinical translation of this technique. These prior studies were performed without an MR-HIFU system specifically developed for breast cancer treatment. In this article, a novel and dedicated MR-HIFU breast platform is presented. This system has been designed for safe and effective MR-HIFU ablation of breast cancer. Furthermore, both clinical and technical challenges are discussed, which have to be solved before MR-HIFU ablation of breast cancer can be implemented in routine clinical practice.},
doi = {10.1007/S00270-012-0526-6},
url = {https://www.osti.gov/biblio/22156359}, journal = {Cardiovascular and Interventional Radiology},
issn = {0174-1551},
number = 2,
volume = 36,
place = {United States},
year = {Mon Apr 15 00:00:00 EDT 2013},
month = {Mon Apr 15 00:00:00 EDT 2013}
}