A common structure for the potexviruses

Journal Article · Tue Feb 05 00:00:00 EST 2013 · Virology

DOI:https://doi.org/10.1016/J.VIROL.2012.11.008· OSTI ID:22150100

Kendall, Amy; Bian, Wen; Maris, Alexander; Azzo, Caitlin; Groom, Joseph ^[1]; Williams, Dewight; Shi, Jian; Stewart, Phoebe L. ^[2]; Wall, Joseph S. ^[3]; Stubbs, Gerald ^[1]

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1. Department of Biological Sciences and Center for Structural Biology, Vanderbilt University, Nashville, TN 37235 (United States)
2. Department of Molecular Physiology and Biophysics and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232 (United States)
3. Biology Department, Brookhaven National Laboratory, Upton, NY 11973 (United States)

We have used fiber diffraction, cryo-electron microscopy, and scanning transmission electron microscopy to confirm the symmetry of three potexviruses, potato virus X, papaya mosaic virus, and narcissus mosaic virus, and to determine their low-resolution structures. All three viruses have slightly less than nine subunits per turn of the viral helix. Our data strongly support the view that all potexviruses have approximately the same symmetry. The structures are dominated by a large domain at high radius in the virion, with a smaller domain, which includes the putative RNA-binding site, extending to low radius.

• OSTI ID: 22150100
• Journal Information: Virology, Vol. 436, Issue 1; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0042-6822
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
PAPAYAS
PLANT DISEASES
POTATOES
TRANSMISSION ELECTRON MICROSCOPY
VIRAL DISEASES
VIRUSES