The role of MAPK in CD4{sup +} T cells toll-like receptor 9-mediated signaling following HHV-6 infection
Abstract
Human herpesvirus-6 (HHV-6) is an important immunosuppressive and immunomodulatory virus that primarily infects immune cells (mainly CD4{sup +} T cells) and strongly suppresses the proliferation of infected cells. Toll-like receptors are pattern-recognition receptors essential for the development of an appropriate innate immune defense against infection. To understand the role of CD4{sup +} T cells in the innate response to HHV-6 infection and the involvement of TLRs, we used an in vitro infection model and observed that the infection of CD4{sup +} T cells resulted in the activation of JNK/SAPK via up-regulation of toll-like receptor 9 (TLR9). Associated with JNK activation, annexin V-PI staining indicated that HHV-6A was a strong inducer of apoptosis. Apoptotic response associated cytokines, IL-6 and TNF-{alpha} also induced by HHV-6A infection.
- Authors:
-
- Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, Jiangsu Province (China)
- Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province (China)
- Department of Developmental Genetics, Nanjing Medical University, Nanjing 210029, Jiangsu Province (China)
- College of Foreign Languages, Hehai University, Nanjing 210029, Jiangsu Province (China)
- Publication Date:
- OSTI Identifier:
- 22149251
- Resource Type:
- Journal Article
- Journal Name:
- Virology
- Additional Journal Information:
- Journal Volume: 422; Journal Issue: 1; Other Information: Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0042-6822
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; APOPTOSIS; CELL PROLIFERATION; IN VITRO; LYMPHOKINES; RECEPTORS; VIRUSES
Citation Formats
Chi, Jing, Wang, Fang, Li, Lingyun, Feng, Dongju, Qin, Jian, Xie, Fangyi, Zhou, Feng, Chen, Yun, Wang, Jinfeng, and Yao, Kun. The role of MAPK in CD4{sup +} T cells toll-like receptor 9-mediated signaling following HHV-6 infection. United States: N. p., 2012.
Web. doi:10.1016/J.VIROL.2011.09.026.
Chi, Jing, Wang, Fang, Li, Lingyun, Feng, Dongju, Qin, Jian, Xie, Fangyi, Zhou, Feng, Chen, Yun, Wang, Jinfeng, & Yao, Kun. The role of MAPK in CD4{sup +} T cells toll-like receptor 9-mediated signaling following HHV-6 infection. United States. https://doi.org/10.1016/J.VIROL.2011.09.026
Chi, Jing, Wang, Fang, Li, Lingyun, Feng, Dongju, Qin, Jian, Xie, Fangyi, Zhou, Feng, Chen, Yun, Wang, Jinfeng, and Yao, Kun. 2012.
"The role of MAPK in CD4{sup +} T cells toll-like receptor 9-mediated signaling following HHV-6 infection". United States. https://doi.org/10.1016/J.VIROL.2011.09.026.
@article{osti_22149251,
title = {The role of MAPK in CD4{sup +} T cells toll-like receptor 9-mediated signaling following HHV-6 infection},
author = {Chi, Jing and Wang, Fang and Li, Lingyun and Feng, Dongju and Qin, Jian and Xie, Fangyi and Zhou, Feng and Chen, Yun and Wang, Jinfeng and Yao, Kun},
abstractNote = {Human herpesvirus-6 (HHV-6) is an important immunosuppressive and immunomodulatory virus that primarily infects immune cells (mainly CD4{sup +} T cells) and strongly suppresses the proliferation of infected cells. Toll-like receptors are pattern-recognition receptors essential for the development of an appropriate innate immune defense against infection. To understand the role of CD4{sup +} T cells in the innate response to HHV-6 infection and the involvement of TLRs, we used an in vitro infection model and observed that the infection of CD4{sup +} T cells resulted in the activation of JNK/SAPK via up-regulation of toll-like receptor 9 (TLR9). Associated with JNK activation, annexin V-PI staining indicated that HHV-6A was a strong inducer of apoptosis. Apoptotic response associated cytokines, IL-6 and TNF-{alpha} also induced by HHV-6A infection.},
doi = {10.1016/J.VIROL.2011.09.026},
url = {https://www.osti.gov/biblio/22149251},
journal = {Virology},
issn = {0042-6822},
number = 1,
volume = 422,
place = {United States},
year = {Thu Jan 05 00:00:00 EST 2012},
month = {Thu Jan 05 00:00:00 EST 2012}
}