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Title: The role of MAPK in CD4{sup +} T cells toll-like receptor 9-mediated signaling following HHV-6 infection

Abstract

Human herpesvirus-6 (HHV-6) is an important immunosuppressive and immunomodulatory virus that primarily infects immune cells (mainly CD4{sup +} T cells) and strongly suppresses the proliferation of infected cells. Toll-like receptors are pattern-recognition receptors essential for the development of an appropriate innate immune defense against infection. To understand the role of CD4{sup +} T cells in the innate response to HHV-6 infection and the involvement of TLRs, we used an in vitro infection model and observed that the infection of CD4{sup +} T cells resulted in the activation of JNK/SAPK via up-regulation of toll-like receptor 9 (TLR9). Associated with JNK activation, annexin V-PI staining indicated that HHV-6A was a strong inducer of apoptosis. Apoptotic response associated cytokines, IL-6 and TNF-{alpha} also induced by HHV-6A infection.

Authors:
 [1];  [2];  [3];  [1];  [4]; ; ; ;  [1];  [1]
  1. Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, Jiangsu Province (China)
  2. Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province (China)
  3. Department of Developmental Genetics, Nanjing Medical University, Nanjing 210029, Jiangsu Province (China)
  4. College of Foreign Languages, Hehai University, Nanjing 210029, Jiangsu Province (China)
Publication Date:
OSTI Identifier:
22149251
Resource Type:
Journal Article
Journal Name:
Virology
Additional Journal Information:
Journal Volume: 422; Journal Issue: 1; Other Information: Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0042-6822
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; APOPTOSIS; CELL PROLIFERATION; IN VITRO; LYMPHOKINES; RECEPTORS; VIRUSES

Citation Formats

Chi, Jing, Wang, Fang, Li, Lingyun, Feng, Dongju, Qin, Jian, Xie, Fangyi, Zhou, Feng, Chen, Yun, Wang, Jinfeng, and Yao, Kun. The role of MAPK in CD4{sup +} T cells toll-like receptor 9-mediated signaling following HHV-6 infection. United States: N. p., 2012. Web. doi:10.1016/J.VIROL.2011.09.026.
Chi, Jing, Wang, Fang, Li, Lingyun, Feng, Dongju, Qin, Jian, Xie, Fangyi, Zhou, Feng, Chen, Yun, Wang, Jinfeng, & Yao, Kun. The role of MAPK in CD4{sup +} T cells toll-like receptor 9-mediated signaling following HHV-6 infection. United States. https://doi.org/10.1016/J.VIROL.2011.09.026
Chi, Jing, Wang, Fang, Li, Lingyun, Feng, Dongju, Qin, Jian, Xie, Fangyi, Zhou, Feng, Chen, Yun, Wang, Jinfeng, and Yao, Kun. 2012. "The role of MAPK in CD4{sup +} T cells toll-like receptor 9-mediated signaling following HHV-6 infection". United States. https://doi.org/10.1016/J.VIROL.2011.09.026.
@article{osti_22149251,
title = {The role of MAPK in CD4{sup +} T cells toll-like receptor 9-mediated signaling following HHV-6 infection},
author = {Chi, Jing and Wang, Fang and Li, Lingyun and Feng, Dongju and Qin, Jian and Xie, Fangyi and Zhou, Feng and Chen, Yun and Wang, Jinfeng and Yao, Kun},
abstractNote = {Human herpesvirus-6 (HHV-6) is an important immunosuppressive and immunomodulatory virus that primarily infects immune cells (mainly CD4{sup +} T cells) and strongly suppresses the proliferation of infected cells. Toll-like receptors are pattern-recognition receptors essential for the development of an appropriate innate immune defense against infection. To understand the role of CD4{sup +} T cells in the innate response to HHV-6 infection and the involvement of TLRs, we used an in vitro infection model and observed that the infection of CD4{sup +} T cells resulted in the activation of JNK/SAPK via up-regulation of toll-like receptor 9 (TLR9). Associated with JNK activation, annexin V-PI staining indicated that HHV-6A was a strong inducer of apoptosis. Apoptotic response associated cytokines, IL-6 and TNF-{alpha} also induced by HHV-6A infection.},
doi = {10.1016/J.VIROL.2011.09.026},
url = {https://www.osti.gov/biblio/22149251}, journal = {Virology},
issn = {0042-6822},
number = 1,
volume = 422,
place = {United States},
year = {Thu Jan 05 00:00:00 EST 2012},
month = {Thu Jan 05 00:00:00 EST 2012}
}