Radioembolization of the Spleen: A Revisited Approach for the Treatment of Malignant Lymphomatous Splenomegaly

Journal Article · Thu Aug 01 00:00:00 EDT 2013 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-012-0484-Z· OSTI ID:22121751

Muylle, Kristoff ^[1]; Nguyen, Jasmine ^[2]; Wind, Alexandre de ^[3]; Meuleman, Nathalie ^[2]; Delatte, Philippe ^[4]; Vanderlinden, Bruno ^[5]; Roelandts, Martine ^[6]; Van der Stappen, Anja ^[7]; Bron, Dominique ^[2]; Flamen, Patrick ^[1]

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1. Jules Bordet Institute, ULB, Department of Nuclear Medicine (Belgium)
2. Jules Bordet Institute, ULB, Department of Haematology (Belgium)
3. Jules Bordet Institute, ULB, Department of Anatomo-Pathology (Belgium)
4. UMC Sint-Pieter, Department of Interventional Radiology (Belgium)
5. Jules Bordet Institute, ULB, Department of Radiophysics (Belgium)
6. Jules Bordet Institute, ULB, Department of Radiotherapy (Belgium)
7. Jules Bordet Institute, ULB, Department of Radiology (Belgium)

Intraarterial administration of {sup 90}Y microspheres to the spleen in patients with malignant lymphoma was mentioned once in the literature in 1973. This case study illustrates the potential indication of selective internal radiotherapy in a heavily pretreated patient with highly refractory disease with a marginal zone lymphoma in leukemic phase and symptomatic splenomegaly. We describe the clinical course of disease; the biological and clinical response to the treatment after radioembolization; and simulation and dosimetry by multimodal imaging via single-photon emission computed tomography and computed tomography. The advantages of radioembolization for the management of lymphomatous splenomegaly are discussed.

• OSTI ID: 22121751
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 36, Issue 4; Other Information: Copyright (c) 2013 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Article Copyright (c) 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
DOSIMETRY
LYMPHOMAS
MICROSPHERES
PATIENTS
RADIOTHERAPY
SIMULATION
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SPLEEN
SPLENOMEGALY
YTTRIUM 90