Comparative performance of multiview stereoscopic and mammographic display modalities for breast lesion detection

Webb, Lincoln J.; Samei, Ehsan; Lo, Joseph Y.; Baker, Jay A.; Ghate, Sujata V.; Kim, Connie; Soo, Mary Scott; Walsh, Ruth

doi:10.1118/1.3562901

Title: Comparative performance of multiview stereoscopic and mammographic display modalities for breast lesion detection

Full Record
Other Related Research

Abstract

Purpose: Mammography is known to be one of the most difficult radiographic exams to interpret. Mammography has important limitations, including the superposition of normal tissue that can obscure a mass, chance alignment of normal tissue to mimic a true lesion and the inability to derive volumetric information. It has been shown that stereomammography can overcome these deficiencies by showing that layers of normal tissue lay at different depths. If standard stereomammography (i.e., a single stereoscopic pair consisting of two projection images) can significantly improve lesion detection, how will multiview stereoscopy (MVS), where many projection images are used, compare to mammography? The aim of this study was to assess the relative performance of MVS compared to mammography for breast mass detection. Methods: The MVS image sets consisted of the 25 raw projection images acquired over an arc of approximately 45 deg. using a Siemens prototype breast tomosynthesis system. The mammograms were acquired using a commercial Siemens FFDM system. The raw data were taken from both of these systems for 27 cases and realistic simulated mass lesions were added to duplicates of the 27 images at the same local contrast. The images with lesions (27 mammography and 27 MVS) and the imagesmore »« less

Authors:

Webb, Lincoln J.; Samei, Ehsan; Lo, Joseph Y.; Baker, Jay A.; Ghate, Sujata V.; Kim, Connie; Soo, Mary Scott; Walsh, Ruth ^[1]

Medical Physics Graduate Program, Carl E. Ravin Advanced Imaging Laboratories, Duke University, Durham, North Carolina 27705 (United States)

Publication Date:: Fri Apr 15 00:00:00 EDT 2011

OSTI Identifier:: 22096969

Resource Type:: Journal Article

Journal Name:: Medical Physics

Additional Journal Information:: Journal Volume: 38; Journal Issue: 4; Other Information: (c) 2011 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; BIOMEDICAL RADIOGRAPHY; COMPARATIVE EVALUATIONS; COMPUTERIZED TOMOGRAPHY; IMAGE PROCESSING; IMAGES; MAMMARY GLANDS; NEOPLASMS; NOISE; PERFORMANCE; SIMULATION; STANDARDS

Citation Formats


                    Webb, Lincoln J., Samei, Ehsan, Lo, Joseph Y., Baker, Jay A., Ghate, Sujata V., Kim, Connie, Soo, Mary Scott, Walsh, Ruth, Department of Radiology, Medical Physics Graduate Program, and Department of Biomedical Engineering, Carl E. Ravin Advanced Imaging Laboratories, Duke University, Durham, North Carolina 27705, Department of Radiology, Carl E. Ravin Advanced Imaging Laboratories, Duke University, Durham, North Carolina 27705, and Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710. Comparative performance of multiview stereoscopic and mammographic display modalities for breast lesion detection.  United States: N. p., 2011. 
        Web.  doi:10.1118/1.3562901.

Copy to clipboard


                    Webb, Lincoln J., Samei, Ehsan, Lo, Joseph Y., Baker, Jay A., Ghate, Sujata V., Kim, Connie, Soo, Mary Scott, Walsh, Ruth, Department of Radiology, Medical Physics Graduate Program, and Department of Biomedical Engineering, Carl E. Ravin Advanced Imaging Laboratories, Duke University, Durham, North Carolina 27705, Department of Radiology, Carl E. Ravin Advanced Imaging Laboratories, Duke University, Durham, North Carolina 27705, & Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710. Comparative performance of multiview stereoscopic and mammographic display modalities for breast lesion detection.  United States.  https://doi.org/10.1118/1.3562901

Copy to clipboard


                    Webb, Lincoln J., Samei, Ehsan, Lo, Joseph Y., Baker, Jay A., Ghate, Sujata V., Kim, Connie, Soo, Mary Scott, Walsh, Ruth, Department of Radiology, Medical Physics Graduate Program, and Department of Biomedical Engineering, Carl E. Ravin Advanced Imaging Laboratories, Duke University, Durham, North Carolina 27705, Department of Radiology, Carl E. Ravin Advanced Imaging Laboratories, Duke University, Durham, North Carolina 27705, and Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710. 2011.  
        "Comparative performance of multiview stereoscopic and mammographic display modalities for breast lesion detection".  United States.  https://doi.org/10.1118/1.3562901.

Copy to clipboard


                    
@article{osti_22096969,

  title        = {Comparative performance of multiview stereoscopic and mammographic display modalities for breast lesion detection},

  author       = {Webb, Lincoln J. and Samei, Ehsan and Lo, Joseph Y. and Baker, Jay A. and Ghate, Sujata V. and Kim, Connie and Soo, Mary Scott and Walsh, Ruth and Department of Radiology, Medical Physics Graduate Program, and Department of Biomedical Engineering, Carl E. Ravin Advanced Imaging Laboratories, Duke University, Durham, North Carolina 27705 and Department of Radiology, Carl E. Ravin Advanced Imaging Laboratories, Duke University, Durham, North Carolina 27705 and Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710},

  abstractNote = {Purpose: Mammography is known to be one of the most difficult radiographic exams to interpret. Mammography has important limitations, including the superposition of normal tissue that can obscure a mass, chance alignment of normal tissue to mimic a true lesion and the inability to derive volumetric information. It has been shown that stereomammography can overcome these deficiencies by showing that layers of normal tissue lay at different depths. If standard stereomammography (i.e., a single stereoscopic pair consisting of two projection images) can significantly improve lesion detection, how will multiview stereoscopy (MVS), where many projection images are used, compare to mammography? The aim of this study was to assess the relative performance of MVS compared to mammography for breast mass detection. Methods: The MVS image sets consisted of the 25 raw projection images acquired over an arc of approximately 45 deg. using a Siemens prototype breast tomosynthesis system. The mammograms were acquired using a commercial Siemens FFDM system. The raw data were taken from both of these systems for 27 cases and realistic simulated mass lesions were added to duplicates of the 27 images at the same local contrast. The images with lesions (27 mammography and 27 MVS) and the images without lesions (27 mammography and 27 MVS) were then postprocessed to provide comparable and representative image appearance across the two modalities. All 108 image sets were shown to five full-time breast imaging radiologists in random order on a state-of-the-art stereoscopic display. The observers were asked to give a confidence rating for each image (0 for lesion definitely not present, 100 for lesion definitely present). The ratings were then compiled and processed using ROC and variance analysis. Results: The mean AUC for the five observers was 0.614{+-}0.055 for mammography and 0.778{+-}0.052 for multiview stereoscopy. The difference of 0.164{+-}0.065 was statistically significant with a p-value of 0.0148. Conclusions: The differences in the AUCs and the p-value suggest that multiview stereoscopy has a statistically significant advantage over mammography in the detection of simulated breast masses. This highlights the dominance of anatomical noise compared to quantum noise for breast mass detection. It also shows that significant lesion detection can be achieved with MVS without any of the artifacts associated with tomosynthesis.},

  doi          = {10.1118/1.3562901},

  url          = {https://www.osti.gov/biblio/22096969},
  journal      = {Medical Physics},

  issn         = {0094-2405},

  number       = 4,

  volume       = 38,

  place        = {United States},

  year         = {Fri Apr 15 00:00:00 EDT 2011},

  month        = {Fri Apr 15 00:00:00 EDT 2011}

}

Copy to clipboard

Journal Article:

https://doi.org/10.1118/1.3562901

Other availability

Find in Google Scholar

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

TU-F-18C-02: Increasing Amorphous Selenium Thickness in Direct Conversion Flat-Panel Imagers for Contrast-Enhanced Dual-Energy Breast Imaging

Journal Article Scaduto, DA; Hu, Y-H; Zhao, W - Medical Physics

Purpose: Contrast-enhanced (CE) breast imaging using iodinated contrast agents requires imaging with x-ray spectra at energies greater than those used in mammography. Optimizing amorphous selenium (a-Se) flat panel imagers (FPI) for this higher energy range may increase lesion conspicuity. Methods: We compare imaging performance of a conventional FPI with 200 μm a-Se conversion layer to a prototype FPI with 300 μm a-Se layer. Both detectors are evaluated in a Siemens MAMMOMAT Inspiration prototype digital breast tomosynthesis (DBT) system using low-energy (W/Rh 28 kVp) and high-energy (W/Cu 49 kVp) x-ray spectra. Detectability of iodinated lesions in dual-energy images is evaluated usingmore »« less
https://doi.org/10.1118/1.4889347
WE-FG-207A-00: Advances in Dedicated Breast CT

Journal Article

Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent. Its sensitivity, especially in dense breasts, is low due to overlapping tissue and the fact that normal breast tissue, benign lesions and breast cancers all have similar “densities”, making lesion detectionmore »« less
https://doi.org/10.1118/1.4957925
WE-FG-207A-01: Introduction to Dedicated Breast CT - Early Studies

Journal Article Vedantham, S. - Medical Physics

Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent. Its sensitivity, especially in dense breasts, is low due to overlapping tissue and the fact that normal breast tissue, benign lesions and breast cancers all have similar “densities”, making lesion detectionmore »« less
https://doi.org/10.1118/1.4957926
WE-FG-207A-02: Why We Need Breast CT? - Clinical Perspective

Journal Article O’Connell, A. - Medical Physics

Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent. Its sensitivity, especially in dense breasts, is low due to overlapping tissue and the fact that normal breast tissue, benign lesions and breast cancers all have similar “densities”, making lesion detectionmore »« less
https://doi.org/10.1118/1.4957927
WE-FG-207A-03: Low-Dose Cone-Beam Breast CT: Physics and Technology Development

Journal Article Boone, J. - Medical Physics

Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent. Its sensitivity, especially in dense breasts, is low due to overlapping tissue and the fact that normal breast tissue, benign lesions and breast cancers all have similar “densities”, making lesion detectionmore »« less
https://doi.org/10.1118/1.4957928

Similar Records