Contrast-enhanced spectral mammography with a photon-counting detector
Abstract
Purpose: Spectral imaging is a method in medical x-ray imaging to extract information about the object constituents by the material-specific energy dependence of x-ray attenuation. The authors have investigated a photon-counting spectral imaging system with two energy bins for contrast-enhanced mammography. System optimization and the potential benefit compared to conventional non-energy-resolved absorption imaging was studied. Methods: A framework for system characterization was set up that included quantum and anatomical noise and a theoretical model of the system was benchmarked to phantom measurements. Results: Optimal combination of the energy-resolved images corresponded approximately to minimization of the anatomical noise, which is commonly referred to as energy subtraction. In that case, an ideal-observer detectability index could be improved close to 50% compared to absorption imaging in the phantom study. Optimization with respect to the signal-to-quantum-noise ratio, commonly referred to as energy weighting, yielded only a minute improvement. In a simulation of a clinically more realistic case, spectral imaging was predicted to perform approximately 30% better than absorption imaging for an average glandularity breast with an average level of anatomical noise. For dense breast tissue and a high level of anatomical noise, however, a rise in detectability by a factor of 6 was predicted.more »
- Authors:
-
- Department of Physics, Royal Institute of Technology, AlbaNova, SE-106 91 Stockholm (Sweden)
- Publication Date:
- OSTI Identifier:
- 22096686
- Resource Type:
- Journal Article
- Journal Name:
- Medical Physics
- Additional Journal Information:
- Journal Volume: 37; Journal Issue: 5; Other Information: (c) 2010 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-2405
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 62 RADIOLOGY AND NUCLEAR MEDICINE; BIOMEDICAL RADIOGRAPHY; CONTRAST MEDIA; ENERGY DEPENDENCE; MAMMARY GLANDS; MINIMIZATION; NOISE; PHANTOMS; PHOTONS; SIGNALS; SIMULATION; X RADIATION; X-RAY DETECTION
Citation Formats
Fredenberg, Erik, Hemmendorff, Magnus, Cederstroem, Bjoern, Aaslund, Magnus, Danielsson, Mats, Sectra Mamea AB, Smidesvaegen 5, SE-171 41 Solna, Department of Physics, Royal Institute of Technology, AlbaNova, SE-106 91 Stockholm, Sectra Mamea AB, Smidesvaegen 5, SE-171 41 Solna, and Department of Physics, Royal Institute of Technology, AlbaNova, SE-106 91 Stockholm. Contrast-enhanced spectral mammography with a photon-counting detector. United States: N. p., 2010.
Web. doi:10.1118/1.3371689.
Fredenberg, Erik, Hemmendorff, Magnus, Cederstroem, Bjoern, Aaslund, Magnus, Danielsson, Mats, Sectra Mamea AB, Smidesvaegen 5, SE-171 41 Solna, Department of Physics, Royal Institute of Technology, AlbaNova, SE-106 91 Stockholm, Sectra Mamea AB, Smidesvaegen 5, SE-171 41 Solna, & Department of Physics, Royal Institute of Technology, AlbaNova, SE-106 91 Stockholm. Contrast-enhanced spectral mammography with a photon-counting detector. United States. https://doi.org/10.1118/1.3371689
Fredenberg, Erik, Hemmendorff, Magnus, Cederstroem, Bjoern, Aaslund, Magnus, Danielsson, Mats, Sectra Mamea AB, Smidesvaegen 5, SE-171 41 Solna, Department of Physics, Royal Institute of Technology, AlbaNova, SE-106 91 Stockholm, Sectra Mamea AB, Smidesvaegen 5, SE-171 41 Solna, and Department of Physics, Royal Institute of Technology, AlbaNova, SE-106 91 Stockholm. 2010.
"Contrast-enhanced spectral mammography with a photon-counting detector". United States. https://doi.org/10.1118/1.3371689.
@article{osti_22096686,
title = {Contrast-enhanced spectral mammography with a photon-counting detector},
author = {Fredenberg, Erik and Hemmendorff, Magnus and Cederstroem, Bjoern and Aaslund, Magnus and Danielsson, Mats and Sectra Mamea AB, Smidesvaegen 5, SE-171 41 Solna and Department of Physics, Royal Institute of Technology, AlbaNova, SE-106 91 Stockholm and Sectra Mamea AB, Smidesvaegen 5, SE-171 41 Solna and Department of Physics, Royal Institute of Technology, AlbaNova, SE-106 91 Stockholm},
abstractNote = {Purpose: Spectral imaging is a method in medical x-ray imaging to extract information about the object constituents by the material-specific energy dependence of x-ray attenuation. The authors have investigated a photon-counting spectral imaging system with two energy bins for contrast-enhanced mammography. System optimization and the potential benefit compared to conventional non-energy-resolved absorption imaging was studied. Methods: A framework for system characterization was set up that included quantum and anatomical noise and a theoretical model of the system was benchmarked to phantom measurements. Results: Optimal combination of the energy-resolved images corresponded approximately to minimization of the anatomical noise, which is commonly referred to as energy subtraction. In that case, an ideal-observer detectability index could be improved close to 50% compared to absorption imaging in the phantom study. Optimization with respect to the signal-to-quantum-noise ratio, commonly referred to as energy weighting, yielded only a minute improvement. In a simulation of a clinically more realistic case, spectral imaging was predicted to perform approximately 30% better than absorption imaging for an average glandularity breast with an average level of anatomical noise. For dense breast tissue and a high level of anatomical noise, however, a rise in detectability by a factor of 6 was predicted. Another {approx}70%-90% improvement was found to be within reach for an optimized system. Conclusions: Contrast-enhanced spectral mammography is feasible and beneficial with the current system, and there is room for additional improvements. Inclusion of anatomical noise is essential for optimizing spectral imaging systems.},
doi = {10.1118/1.3371689},
url = {https://www.osti.gov/biblio/22096686},
journal = {Medical Physics},
issn = {0094-2405},
number = 5,
volume = 37,
place = {United States},
year = {Sat May 15 00:00:00 EDT 2010},
month = {Sat May 15 00:00:00 EDT 2010}
}