Routine production of copper-64 using 11.7MeV protons

Journal Article · Wed Dec 19 00:00:00 EST 2012 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4773946· OSTI ID:22075958

Jeffery, C M; Smith, S V; Asad, A H; Chan, S; Price, R I ^[1]

---

1. Medical Technology and Physics, Sir Charles Gairdner Hospital, Nedlands, Western Australia, 6009 (Australia)

Reliable production of copper-64 ({sup 64}Cu) was achieved by irradiating enriched nickel-64 ({sup 64}Ni, >94.8%) in an IBA 18/9 cyclotron. Nickel-64 (19.1 {+-} 3.0 mg) was electroplated onto an Au disc (125{mu}m Multiplication-Sign 15mm). Targets were irradiated with 11.7 MeV protons for 2 hours at 40{mu}A. Copper isotopes ({sup 60,61,62,64}Cu) were separated from target nickel and cobalt isotopes ({sup 55,57,61}Co) using a single ion exchange column, eluted with varying concentration of low HCl alcohol solutions. The {sup 64}Ni target material was recovered and reused. The {sup 64}Cu production rate was 1.46{+-}0.3MBq/{mu}A.hr/mg{sup 64}Ni(n = 10) (with a maximum of 2.6GBq of {sup 64}Cu isolated after 2hr irradiation at 40uA. Radionuclidic purity of the {sup 64}Cu was 98.7 {+-} 1.6 % at end of separation. Cu content was < 6mg/L (n = 21). The specific activity of {sup 64}Cu was determined by ICP-MS and by titration with Diamsar to be 28.9{+-}13.0GBq/{mu}mol[0.70{+-}0.35Ci/{mu}mol]/({mu}A.hr/mg{sup 64}Ni)(n = 10) and 13.1{+-}12.0GBq/{mu}mol[0.35{+-}0.32Ci/{mu}mol]/({mu}A.hr/mg{sup 64}Ni)(n 9), respectively; which are in agreement, however, further work is required.

• OSTI ID: 22075958
• Journal Information: AIP Conference Proceedings, Vol. 1509, Issue 1; Conference: 14. international workshop on targetry and target chemistry, Playa del Carmen (Mexico), 26-29 Aug 2012; Other Information: (c) 2012 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

07 ISOTOPES AND RADIATION SOURCES
38 RADIATION CHEMISTRY
RADIOCHEMISTRY AND NUCLEAR CHEMISTRY
ALCOHOLS
COBALT 61
COPPER 64
CYCLOTRONS
ELECTROPLATING
GOLD IONS
HYDROCHLORIC ACID
ICP MASS SPECTROSCOPY
IMPURITIES
ION EXCHANGE
IRRADIATION
ISOTOPE PRODUCTION
ISOTOPE SEPARATION
MEV RANGE
NICKEL 64
PROTON REACTIONS
RADIOCHEMISTRY
TITRATION