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Title: Histological evaluation of high-intensity focused ultrasound with lower-intensity focused ultrasound pre-exposure on the treatment of rabbit VX2 liver tumors

Abstract

This study was to evaluate the effect of pre-exposure lower-intensity focused ultrasound(US), or LIFU, in high-intensity focused ultrasound(HIFU) ablation of rabbit VX2 liver tumors . Liver VX2 tumor models were established in 30 rabbits, which were divided randomly into two groups. The liver tumors of rabbits in Group A underwent single HIFU ablation; those in Group B were given LIFU exposure before HIFU treatment. Five rabbits from each of the two groups were sacrificed at 0 hours, 3 days, and 7 days after HIFU ablation. Tissue samples that included targeted and short-range sounding (s-RS, within 5 mm of the targeted) and far-range sounding (f-RS, more than 5 mm of the targeted) tissues were observed using light microscope and transmission electron microscopy. The histological examination indicated that not only the targeted tumor cells became irreversible damage, but also the short-range sounding tumors were severely damaged by the HIFU with LIFU pre-exposure in group B. It is concluded that LIFU pre-exposure can enhance the effects of HIFU ablation on the destruction of cell ultrastructures and can enlarge the region of HIFU ablation.

Authors:
; ; ;  [1]
  1. State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, Department of Biomedical Engineering, Chongqing Medical (China)
Publication Date:
OSTI Identifier:
22075585
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1481; Journal Issue: 1; Conference: 11. international symposium on therapeutic ultrasound, New York, NY (United States), 11-13 Apr 2011; Other Information: (c) 2012 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ABLATION; BIOLOGICAL EFFECTS; EVALUATION; LIVER; NEOPLASMS; OPTICAL MICROSCOPY; RABBITS; THERAPY; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELLS; ULTRASONOGRAPHY; VISIBLE RADIATION

Citation Formats

Hairong, Zou, Jianzhong, Zou, Yan, Wang, and Xia, Ou. Histological evaluation of high-intensity focused ultrasound with lower-intensity focused ultrasound pre-exposure on the treatment of rabbit VX2 liver tumors. United States: N. p., 2012. Web. doi:10.1063/1.4757383.
Hairong, Zou, Jianzhong, Zou, Yan, Wang, & Xia, Ou. Histological evaluation of high-intensity focused ultrasound with lower-intensity focused ultrasound pre-exposure on the treatment of rabbit VX2 liver tumors. United States. https://doi.org/10.1063/1.4757383
Hairong, Zou, Jianzhong, Zou, Yan, Wang, and Xia, Ou. 2012. "Histological evaluation of high-intensity focused ultrasound with lower-intensity focused ultrasound pre-exposure on the treatment of rabbit VX2 liver tumors". United States. https://doi.org/10.1063/1.4757383.
@article{osti_22075585,
title = {Histological evaluation of high-intensity focused ultrasound with lower-intensity focused ultrasound pre-exposure on the treatment of rabbit VX2 liver tumors},
author = {Hairong, Zou and Jianzhong, Zou and Yan, Wang and Xia, Ou},
abstractNote = {This study was to evaluate the effect of pre-exposure lower-intensity focused ultrasound(US), or LIFU, in high-intensity focused ultrasound(HIFU) ablation of rabbit VX2 liver tumors . Liver VX2 tumor models were established in 30 rabbits, which were divided randomly into two groups. The liver tumors of rabbits in Group A underwent single HIFU ablation; those in Group B were given LIFU exposure before HIFU treatment. Five rabbits from each of the two groups were sacrificed at 0 hours, 3 days, and 7 days after HIFU ablation. Tissue samples that included targeted and short-range sounding (s-RS, within 5 mm of the targeted) and far-range sounding (f-RS, more than 5 mm of the targeted) tissues were observed using light microscope and transmission electron microscopy. The histological examination indicated that not only the targeted tumor cells became irreversible damage, but also the short-range sounding tumors were severely damaged by the HIFU with LIFU pre-exposure in group B. It is concluded that LIFU pre-exposure can enhance the effects of HIFU ablation on the destruction of cell ultrastructures and can enlarge the region of HIFU ablation.},
doi = {10.1063/1.4757383},
url = {https://www.osti.gov/biblio/22075585}, journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1481,
place = {United States},
year = {Wed Oct 03 00:00:00 EDT 2012},
month = {Wed Oct 03 00:00:00 EDT 2012}
}