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Title: Preliminary Experience in Treatment of Papillary and Macular Retinoblastoma: Evaluation of Local Control and Local Complications After Treatment With Linear Accelerator-Based Stereotactic Radiotherapy With Micromultileaf Collimator as Second-Line or Salvage Treatment After Chemotherapy

Abstract

Purpose: To determine the local control and complication rates for children with papillary and/or macular retinoblastoma progressing after chemotherapy and undergoing stereotactic radiotherapy (SRT) with a micromultileaf collimator. Methods and Materials: Between 2004 and 2008, 11 children (15 eyes) with macular and/or papillary retinoblastoma were treated with SRT. The mean age was 19 months (range, 2-111). Of the 15 eyes, 7, 6, and 2 were classified as International Classification of Intraocular Retinoblastoma Group B, C, and E, respectively. The delivered dose of SRT was 50.4 Gy in 28 fractions using a dedicated micromultileaf collimator linear accelerator. Results: The median follow-up was 20 months (range, 13-39). Local control was achieved in 13 eyes (87%). The actuarial 1- and 2-year local control rates were both 82%. SRT was well tolerated. Late adverse events were reported in 4 patients. Of the 4 patients, 2 had developed focal microangiopathy 20 months after SRT; 1 had developed a transient recurrence of retinal detachment; and 1 had developed bilateral cataracts. No optic neuropathy was observed. Conclusions: Linear accelerator-based SRT for papillary and/or macular retinoblastoma in children resulted in excellent tumor control rates with acceptable toxicity. Additional research regarding SRT and its intrinsic organ-at-risk sparing capability ismore » justified in the framework of prospective trials.« less

Authors:
 [1];  [2];  [3];  [4];  [5];  [2];  [6];  [3]
  1. Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland)
  2. University Institute for Radiation Physics, Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland)
  3. Department of Radiation Oncology, Jules Gonin Eye Hospital, Lausanne (Switzerland)
  4. Unit of Pediatric Oncology, University of Lausanne, Lausanne (Switzerland)
  5. Department of Anesthesiology, University of Lausanne, Lausanne (Switzerland)
  6. Department of Radiation Oncology, Geneva University Hospital, University of Geneva, Geneva (Switzerland)
Publication Date:
OSTI Identifier:
22054494
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 81; Journal Issue: 5; Other Information: Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CATARACTS; CHEMOTHERAPY; CHILDREN; CLASSIFICATION; EYES; HAZARDS; LINEAR ACCELERATORS; NEOPLASMS; PATIENTS; RADIATION DOSES; RADIOTHERAPY; TOXICITY

Citation Formats

Pica, Alessia, Moeckli, Raphael, Balmer, Aubin, Beck-Popovic, Maja, Chollet-Rivier, Madeleine, Do, Huu-Phuoc, Weber, Damien C, and Munier, Francis L. Preliminary Experience in Treatment of Papillary and Macular Retinoblastoma: Evaluation of Local Control and Local Complications After Treatment With Linear Accelerator-Based Stereotactic Radiotherapy With Micromultileaf Collimator as Second-Line or Salvage Treatment After Chemotherapy. United States: N. p., 2011. Web. doi:10.1016/J.IJROBP.2010.07.033.
Pica, Alessia, Moeckli, Raphael, Balmer, Aubin, Beck-Popovic, Maja, Chollet-Rivier, Madeleine, Do, Huu-Phuoc, Weber, Damien C, & Munier, Francis L. Preliminary Experience in Treatment of Papillary and Macular Retinoblastoma: Evaluation of Local Control and Local Complications After Treatment With Linear Accelerator-Based Stereotactic Radiotherapy With Micromultileaf Collimator as Second-Line or Salvage Treatment After Chemotherapy. United States. https://doi.org/10.1016/J.IJROBP.2010.07.033
Pica, Alessia, Moeckli, Raphael, Balmer, Aubin, Beck-Popovic, Maja, Chollet-Rivier, Madeleine, Do, Huu-Phuoc, Weber, Damien C, and Munier, Francis L. 2011. "Preliminary Experience in Treatment of Papillary and Macular Retinoblastoma: Evaluation of Local Control and Local Complications After Treatment With Linear Accelerator-Based Stereotactic Radiotherapy With Micromultileaf Collimator as Second-Line or Salvage Treatment After Chemotherapy". United States. https://doi.org/10.1016/J.IJROBP.2010.07.033.
@article{osti_22054494,
title = {Preliminary Experience in Treatment of Papillary and Macular Retinoblastoma: Evaluation of Local Control and Local Complications After Treatment With Linear Accelerator-Based Stereotactic Radiotherapy With Micromultileaf Collimator as Second-Line or Salvage Treatment After Chemotherapy},
author = {Pica, Alessia and Moeckli, Raphael and Balmer, Aubin and Beck-Popovic, Maja and Chollet-Rivier, Madeleine and Do, Huu-Phuoc and Weber, Damien C and Munier, Francis L},
abstractNote = {Purpose: To determine the local control and complication rates for children with papillary and/or macular retinoblastoma progressing after chemotherapy and undergoing stereotactic radiotherapy (SRT) with a micromultileaf collimator. Methods and Materials: Between 2004 and 2008, 11 children (15 eyes) with macular and/or papillary retinoblastoma were treated with SRT. The mean age was 19 months (range, 2-111). Of the 15 eyes, 7, 6, and 2 were classified as International Classification of Intraocular Retinoblastoma Group B, C, and E, respectively. The delivered dose of SRT was 50.4 Gy in 28 fractions using a dedicated micromultileaf collimator linear accelerator. Results: The median follow-up was 20 months (range, 13-39). Local control was achieved in 13 eyes (87%). The actuarial 1- and 2-year local control rates were both 82%. SRT was well tolerated. Late adverse events were reported in 4 patients. Of the 4 patients, 2 had developed focal microangiopathy 20 months after SRT; 1 had developed a transient recurrence of retinal detachment; and 1 had developed bilateral cataracts. No optic neuropathy was observed. Conclusions: Linear accelerator-based SRT for papillary and/or macular retinoblastoma in children resulted in excellent tumor control rates with acceptable toxicity. Additional research regarding SRT and its intrinsic organ-at-risk sparing capability is justified in the framework of prospective trials.},
doi = {10.1016/J.IJROBP.2010.07.033},
url = {https://www.osti.gov/biblio/22054494}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 5,
volume = 81,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 2011},
month = {Thu Dec 01 00:00:00 EST 2011}
}