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Title: Laser speckle-imaging of blood microcirculation in the brain cortex of laboratory rats in stress

Abstract

The results of experimental approbation of the method of laser full-field speckle-imaging for monitoring the changes in blood microcirculation state of the brain cortex of laboratory rats under the conditions of developing stroke and administration of vasodilating and vasoconstrictive agents are presented. The studies aimed at the choice of the optimal conditions of speckle-image formation and recording were performed and the software implementing an adaptive algorithm for processing the data of measurements was created. The transfer of laser radiation to the probed region of the biotissue was implemented by means of a silica-polymer optical fibre. The problems and prospects of speckle-imaging of cerebral microcirculation of blood in laboratory and clinical conditions are discussed.

Authors:
; ; ; ; ; ;
Publication Date:
OSTI Identifier:
22043940
Resource Type:
Journal Article
Journal Name:
Quantum Electronics (Woodbury, N.Y.)
Additional Journal Information:
Journal Volume: 42; Journal Issue: 6; Other Information: Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 1063-7818
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; ALGORITHMS; BIOPHYSICS; BLOOD; BRAIN; IMAGES; LASER RADIATION; OPTICAL FIBERS; RATS; SILICA; STRESSES

Citation Formats

Vilensky, M A, Semyachkina-Glushkovskaya, Oxana V, Timoshina, P A, Kuznetsova, Jana V, Semyachkin-Glushkovskii, I A, Agafonov, Dmitry N, and Tuchin, Valerii V. Laser speckle-imaging of blood microcirculation in the brain cortex of laboratory rats in stress. United States: N. p., 2012. Web. doi:10.1070/QE2012V042N06ABEH014887.
Vilensky, M A, Semyachkina-Glushkovskaya, Oxana V, Timoshina, P A, Kuznetsova, Jana V, Semyachkin-Glushkovskii, I A, Agafonov, Dmitry N, & Tuchin, Valerii V. Laser speckle-imaging of blood microcirculation in the brain cortex of laboratory rats in stress. United States. https://doi.org/10.1070/QE2012V042N06ABEH014887
Vilensky, M A, Semyachkina-Glushkovskaya, Oxana V, Timoshina, P A, Kuznetsova, Jana V, Semyachkin-Glushkovskii, I A, Agafonov, Dmitry N, and Tuchin, Valerii V. 2012. "Laser speckle-imaging of blood microcirculation in the brain cortex of laboratory rats in stress". United States. https://doi.org/10.1070/QE2012V042N06ABEH014887.
@article{osti_22043940,
title = {Laser speckle-imaging of blood microcirculation in the brain cortex of laboratory rats in stress},
author = {Vilensky, M A and Semyachkina-Glushkovskaya, Oxana V and Timoshina, P A and Kuznetsova, Jana V and Semyachkin-Glushkovskii, I A and Agafonov, Dmitry N and Tuchin, Valerii V},
abstractNote = {The results of experimental approbation of the method of laser full-field speckle-imaging for monitoring the changes in blood microcirculation state of the brain cortex of laboratory rats under the conditions of developing stroke and administration of vasodilating and vasoconstrictive agents are presented. The studies aimed at the choice of the optimal conditions of speckle-image formation and recording were performed and the software implementing an adaptive algorithm for processing the data of measurements was created. The transfer of laser radiation to the probed region of the biotissue was implemented by means of a silica-polymer optical fibre. The problems and prospects of speckle-imaging of cerebral microcirculation of blood in laboratory and clinical conditions are discussed.},
doi = {10.1070/QE2012V042N06ABEH014887},
url = {https://www.osti.gov/biblio/22043940}, journal = {Quantum Electronics (Woodbury, N.Y.)},
issn = {1063-7818},
number = 6,
volume = 42,
place = {United States},
year = {Sat Jun 30 00:00:00 EDT 2012},
month = {Sat Jun 30 00:00:00 EDT 2012}
}