An evaluation of anti-oxidative protection for cells against atmospheric pressure cold plasma treatment

Journal Article · Mon Mar 19 00:00:00 EDT 2012 · Applied Physics Letters

DOI:https://doi.org/10.1063/1.3693165· OSTI ID:22025483

Ruonan, Ma; Qian, Zhang ^[1]; Hongqing, Feng; Yongdong, Liang ^[2]; Fangting, Li ^[1]; Weidong, Zhu ^[3]; Jue, Zhang; Jing, Fang ^[1]; Becker, Kurt H ^[4]

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1. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871 (China)
2. College of Engineering, Peking University, Beijing 100871 (China)
3. Department of Applied Science and Technology, Saint Peter's College, Jersey City, New Jersey 07306 (United States)
4. Department of Applied Physics, Polytechnic Institute of New York University, Brooklyn, New York 11201 (United States)

With the development of plasma medicine, safety issues are emerging as a serious concern. In this study, both intracellular (genetic engineering) and extracellular (scavengers) measures were tested in an effort to determine the best protection for cells against plasma-induced oxidative stress. All results of immediate reactive species detection, short term survival and long term proliferation, suggest that intracellular pathways are superior in reducing oxidative stress and cell death. This work provides a potential mechanism to enhance safety and identifies precautionary measures that should be taken in future clinical applications of plasmas.

• OSTI ID: 22025483
• Journal Information: Applied Physics Letters, Vol. 100, Issue 12; Other Information: (c) 2012 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 0003-6951
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANIMAL CELLS
APOPTOSIS
ATMOSPHERIC PRESSURE
BIOPHYSICS
COLD PLASMA
DRUGS
EVALUATION
GENETIC ENGINEERING
MEDICINE
OXIDATION
PATIENTS
STRESSES