The NACP/synuclein gene: Chromosomal assignment and screening for alterations in Alzheimer disease

Journal Article · Mon Mar 20 00:00:00 EST 1995 · Genomics

DOI:https://doi.org/10.1016/0888-7543(95)80208-4· OSTI ID:219887

Campion, D ^[1]; Martin, C; Charbonnier, F ^[2]

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1. CHR, Rouen (France)
2. Unite de Genetique, Rouen (France); and others

The major component of the vascular and plaque amyloid deposits in Alzheimer disease is the amyloid {beta} peptide (A{beta}). A second intrinsic component of amyloid, the NAC (non-A{beta} component of amyloid) peptide, has recently been identified, and its precursor protein was named NACP. A computer homology search allowed us to establish that the human NACP gene was homologous to the rat synuclein gene. We mapped the NACP/synuclein gene to chromosome 4 and cloned three alternatively spliced transcripts in lymphocytes derived from a normal subject. We analyzed by RT-PCR and direct sequencing the entire coding region of the NACP/synuclein gene in a group of patients with familial early onset Alzheimer disease. No mutation was found in 26 unrelated patients. Further studies are required to investigate the implication of the NACP/synuclein gene in Alzheimer disease. 21 refs., 3 tabs.

• OSTI ID: 219887
• Journal Information: Genomics, Vol. 26, Issue 2; Other Information: PBD: 20 Mar 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN CHROMOSOMES
GENETIC MAPPING
GENES
DNA SEQUENCING
TRANSCRIPTION
DNA-CLONING
NERVOUS SYSTEM DISEASES
SCREENING
PEPTIDES
RECESSIVE MUTATIONS
HEREDITARY DISEASES
MENTAL DISORDERS
POLYMERASE CHAIN REACTION