Calculation of complex DNA damage induced by ions
- Department of Physics, Oakland University, Rochester, Michigan 48309 (United States)
- Frankfurt Institute for Advanced Studies, Ruth-Moufang-Strasse 1, D-60438 Frankfurt am Main (Germany)
This paper is devoted to the analysis of the complex damage of DNA irradiated by ions. The assessment of complex damage is important because cells in which it occurs are less likely to survive because the DNA repair mechanisms may not be sufficiently effective. We study the flux of secondary electrons through the surface of nucleosomes and calculate the radial dose and the distribution of clustered damage around the ion's path. The calculated radial dose distribution is compared to simulations. The radial distribution of the complex damage is found to be different from that of the dose. A comparison with experiments may solve the question of what is more lethal for the cell, damage complexity or absorbed energy. We suggest a way to calculate the probability of cell death based on the complexity of the damage. This work is done within the framework of the phenomenon-based multiscale approach to radiation damage by ions.
- OSTI ID:
- 21612315
- Journal Information:
- Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics (Print), Vol. 84, Issue 5; Other Information: DOI: 10.1103/PhysRevE.84.051918; (c) 2011 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); ISSN 1539-3755
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
APOPTOSIS
COMPUTERIZED SIMULATION
DNA
DNA DAMAGES
DNA REPAIR
ELECTRONS
ION BEAMS
NUCLEOSOMES
PHYSICAL RADIATION EFFECTS
PROBABILITY
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
SPATIAL DISTRIBUTION
BEAMS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHROMATIN
DISTRIBUTION
DOSES
ELEMENTARY PARTICLES
FERMIONS
LEPTONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
REPAIR
SIMULATION