Sustained Growth of the Ex Vivo Ablation Zones' Critical Short Axis Using Gas-cooled Radiofrequency Applicators

Journal Article · Tue Feb 15 00:00:00 EST 2011 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-010-9946-3· OSTI ID:21608813

Rempp, Hansjoerg ^[1]; Scharpf, Marcus ^[2]; Voigtlaender, Matthias ^[3]; Schraml, Christina; Schmidt, Diethard ^[1]; Fend, Falko ^[2]; Claussen, Claus D ^[1]; Enderle, Markus D ^[3]; Pereira, Philippe L ^[4]; Clasen, Stephan ^[1]

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1. Eberhard Karls University of Tuebingen, Department of Diagnostic and Interventional Radiology (Germany)
2. Insitute of Pathology, Eberhard Karls University of Tuebingen, Department of General Pathology and Pathological Anatomy (Germany)
3. ERBE Elektromedizin GmbH (Germany)
4. Klinik fuer Radiologie, Minimalinvasive Therapien und Nuklearmedizin (Germany)

Purpose: To evaluate the ablation zones created with a gas-cooled bipolar radiofrequency applicator performed on ex vivo bovine liver tissue. Materials and Methods: A total of 320 ablations with an internally gas-cooled bipolar radiofrequency applicator were performed on fresh ex vivo bovine liver tissue, varying the ablation time (5, 10, 15, and 20 min), power (20, 30, 40, and 50 W), and gas pressure of the CO{sub 2} used for cooling (585, 600, 615, 630, 645 psi), leading to a total of 80 different parameter combinations. Size and shape of the white coagulation zone were assessed. Results: The largest complete ablation zone was achieved after 20 min of implementing 50 W and 645 psi, resulting in a short axis of mean 46 {+-} 1 mm and a long axis of 56 {+-} 2 mm (mean {+-} standard deviation). Short-axis diameters increased between 5 and 20 min of ablation time at 585 psi (increase of the short axis was 45% at 30 W, 29% at 40 W, and 39% at 50 W). This increase was larger at 645 psi (113% at 30 W, 67% at 40 W, and 70% at 50 W). Macroscopic assessment and NADH (nicotinamide adenine dinucleotide) staining revealed incompletely ablated tissue along the needle track in 18 parameter combinations including low-power settings (20 and 30 W) and different cooling levels and ablation times. Conclusion: Gas-cooled radiofrequency applicators increase the short-axis diameter of coagulation in an ex vivo setting if appropriate parameters are selected.

• OSTI ID: 21608813
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 34, Issue 1; Conference: BSIR 2010: Annual meeting of the British Society of Interventional Radiology, Liverpool (United Kingdom), 3-5 Nov 2010; Other Information: DOI: 10.1007/s00270-010-9946-3; Copyright (c) 2011 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ABLATION
CARBON DIOXIDE
CATTLE
LIVER
MATERIALS
PARTICLE TRACKS
RADIOWAVE RADIATION
SHAPE
STANDARDS
ANIMALS
BODY
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
ELECTROMAGNETIC RADIATION
GLANDS
MAMMALS
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIATIONS
RUMINANTS
VERTEBRATES