Lung Tumor Radiofrequency Ablation: Where Do We Stand?

Journal Article · Fri Apr 15 00:00:00 EDT 2011 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-010-9860-8· OSTI ID:21608726

Baere, Thierry de, E-mail: [e-mail] ^[1]

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1. Institut Gustave Roussy, Department of Interventional Radiology (France)

Today, radiofrequency ablation (RFA) of primary and metastatic lung tumor is increasingly used. Because RFA is most often used with curative intent, preablation workup must be a preoperative workup. General anesthesia provides higher feasibility than conscious sedation. The electrode positioning must be performed under computed tomography for sake of accuracy. The delivery of RFA must be adapted to tumor location, with different impedances used when treating tumors with or without pleural contact. The estimated rate of incomplete local treatment at 18 months was 7% (95% confidence interval, 3-14) per tumor, with incomplete treatment depicted at 4 months (n = 1), 6 months (n = 2), 9 months (n = 2), and 12 months (n = 2). Overall survival and lung disease-free survival at 18 months were, respectively, 71 and 34%. Size is a key point for tumor selection because large size is predictive of incomplete local treatment and poor survival. The ratio of ablation volume relative to tumor volume is predictive of complete ablation. Follow-up computed tomography that relies on the size of the ablation zone demonstrates the presence of incomplete ablation. Positron emission tomography might be an interesting option. Chest tube placement for pneumothorax is reported in 8 to 12%. Alveolar hemorrhage and postprocedure hemoptysis occurred in approximately 10% of procedures and rarely required specific treatment. Death was mostly related to single-lung patients and hilar tumors. No modification of forced expiratory volume in the first second between pre- and post-RFA at 2 months was found. RFA in the lung provides a high local efficacy rate. The use of RFA as a palliative tool in combination with chemotherapy remains to be explored.

• OSTI ID: 21608726
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 34, Issue 2; Other Information: DOI: 10.1007/s00270-010-9860-8; Copyright (c) 2011 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ABLATION
ACCURACY
ANESTHESIA
CHEMOTHERAPY
CHEST
HEMORRHAGE
LUNGS
METASTASES
NEOPLASMS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIOWAVE RADIATION
BODY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTROMAGNETIC RADIATION
EMISSION COMPUTED TOMOGRAPHY
MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIATIONS
RESPIRATORY SYSTEM
SYMPTOMS
THERAPY
TOMOGRAPHY