Angiography in the Isolated Perfused Kidney: Radiological Evaluation of Vascular Protection in Tissue Ablation by Nonthermal Irreversible Electroporation

Journal Article · Sun Apr 15 00:00:00 EDT 2012 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-011-0187-X· OSTI ID:21608559

Pech, Maciej ^[1]; Blaschke, Simon; Porsch, Markus; Janitzky, Andreas; Ulrich, Matthias ^[2]; Dudeck, Oliver; Ricke, Jens ^[1]; Liehr, Uwe-Bernd ^[2]

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1. University of Magdeburg, Department of Radiology and Nuclear Medicine (Germany)
2. University of Magdeburg, Department of Urology (Germany)

Purpose: The nonthermal irreversible electroporation (NTIRE) is a novel nonthermal tissue ablation technique by local application of high-voltage current within microseconds leading to a delayed apoptosis. The purpose of this experimental study was the first angiographic evaluation of the acute damage of renal vascular structure in NTIRE. Methods: Results of conventional dynamic digital substraction angiography (DSA) and visualization of the terminal vascular bed of renal parenchyma by high-resolution X-ray in mammography technique were evaluated before, during, and after NTIRE of three isolated perfused porcine ex vivo kidneys. Results: In the dedicated investigation, no acute vascular destruction of the renal parenchyma and no dysfunction of the kidney perfusion model were observed during or after NTIRE. Conspicuous were concentric wave-like fluctuations of the DSA contrast agent simultaneous to the NTIRE pulses resulting from NTIRE pulse shock wave. Conclusion: The NTIRE offers an ablation method with no acute collateral vascular damage in angiographic evaluation.

• OSTI ID: 21608559
• Journal Information: Cardiovascular and Interventional Radiology, Vol. 35, Issue 2; Other Information: DOI: 10.1007/s00270-011-0187-x; Copyright (c) 2012 Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE); Country of input: International Atomic Energy Agency (IAEA); ISSN 0174-1551
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ABLATION
APOPTOSIS
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
EVALUATION
KIDNEYS
MAMMARY GLANDS
PULSES
SAFETY
X RADIATION
BODY
CARDIOVASCULAR SYSTEM
DIAGNOSTIC TECHNIQUES
ELECTROMAGNETIC RADIATION
GLANDS
IONIZING RADIATIONS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATIONS
RADIOLOGY