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Title: Hard X-ray Phase-Contrast Tomographic Nanoimaging

Abstract

Synchrotron-based full-field tomographic microscopy established itself as a tool for noninvasive investigations. Many beamlines worldwide routinely achieve micrometer spatial resolution while the isotropic 100-nm barrier is reached and trespassed only by few instruments, mainly in the soft x-ray regime. We present an x-ray, full-field microscope with tomographic capabilities operating at 10 keV and with a 3D isotropic resolution of 144 nm recently installed at the TOMCAT beamline of the Swiss Light Source. Custom optical components, including a beam-shaping condenser and phase-shifting dot arrays, were used to obtain an ideal, aperture-matched sample illumination and very sensitive phase-contrast imaging. The instrument has been successfully used for the nondestructive, volumetric investigation of single, unstained cells.

Authors:
 [1]; ; ; ; ;  [1]; ;  [2]
  1. Paul Scherrer Institut, 5232 Villigen (Switzerland)
  2. EMPA, Swiss Federal Laboratories for Materials Science and Technology, 8600 Duebendorf (Switzerland)
Publication Date:
OSTI Identifier:
21608288
Resource Type:
Journal Article
Journal Name:
AIP Conference Proceedings
Additional Journal Information:
Journal Volume: 1365; Journal Issue: 1; Conference: 10. international conference on X-ray microscopy, Chicago, IL (United States), 15-20 Aug 2010; Other Information: DOI: 10.1063/1.3625348; (c) 2011 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0094-243X
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS; ANTENNAS; APERTURES; BEAM OPTICS; BEAM SHAPING; BEAM TRANSPORT; HARD X RADIATION; ILLUMINANCE; KEV RANGE; MICROSCOPY; SOFT X RADIATION; SPATIAL RESOLUTION; SWISS LIGHT SOURCE; SYNCHROTRON RADIATION; SYNCHROTRONS; TOMOGRAPHY; X-RAY SOURCES; ACCELERATORS; BREMSSTRAHLUNG; CYCLIC ACCELERATORS; DIAGNOSTIC TECHNIQUES; ELECTRICAL EQUIPMENT; ELECTROMAGNETIC RADIATION; ENERGY RANGE; EQUIPMENT; IONIZING RADIATIONS; OPENINGS; RADIATION SOURCES; RADIATIONS; RESOLUTION; SYNCHROTRON RADIATION SOURCES; X RADIATION

Citation Formats

Stampanoni, M, Institute for Biomedical Engineering, University and ETH Zuerich, 8092 Zuerich, Marone, F, Vila-Comamala, J, Gorelick, S, David, C, Mokso, R, Trtik, P, and Jefimovs, K. Hard X-ray Phase-Contrast Tomographic Nanoimaging. United States: N. p., 2011. Web. doi:10.1063/1.3625348.
Stampanoni, M, Institute for Biomedical Engineering, University and ETH Zuerich, 8092 Zuerich, Marone, F, Vila-Comamala, J, Gorelick, S, David, C, Mokso, R, Trtik, P, & Jefimovs, K. Hard X-ray Phase-Contrast Tomographic Nanoimaging. United States. https://doi.org/10.1063/1.3625348
Stampanoni, M, Institute for Biomedical Engineering, University and ETH Zuerich, 8092 Zuerich, Marone, F, Vila-Comamala, J, Gorelick, S, David, C, Mokso, R, Trtik, P, and Jefimovs, K. 2011. "Hard X-ray Phase-Contrast Tomographic Nanoimaging". United States. https://doi.org/10.1063/1.3625348.
@article{osti_21608288,
title = {Hard X-ray Phase-Contrast Tomographic Nanoimaging},
author = {Stampanoni, M and Institute for Biomedical Engineering, University and ETH Zuerich, 8092 Zuerich and Marone, F and Vila-Comamala, J and Gorelick, S and David, C and Mokso, R and Trtik, P and Jefimovs, K},
abstractNote = {Synchrotron-based full-field tomographic microscopy established itself as a tool for noninvasive investigations. Many beamlines worldwide routinely achieve micrometer spatial resolution while the isotropic 100-nm barrier is reached and trespassed only by few instruments, mainly in the soft x-ray regime. We present an x-ray, full-field microscope with tomographic capabilities operating at 10 keV and with a 3D isotropic resolution of 144 nm recently installed at the TOMCAT beamline of the Swiss Light Source. Custom optical components, including a beam-shaping condenser and phase-shifting dot arrays, were used to obtain an ideal, aperture-matched sample illumination and very sensitive phase-contrast imaging. The instrument has been successfully used for the nondestructive, volumetric investigation of single, unstained cells.},
doi = {10.1063/1.3625348},
url = {https://www.osti.gov/biblio/21608288}, journal = {AIP Conference Proceedings},
issn = {0094-243X},
number = 1,
volume = 1365,
place = {United States},
year = {Fri Sep 09 00:00:00 EDT 2011},
month = {Fri Sep 09 00:00:00 EDT 2011}
}